Browsing by Author "Meyer, Mervin"
Now showing items 1-20 of 28
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Analysis, expression profiling and characterization of hsa-miR-5698 target genes as putative dynamic network biomarkers for prostate cancer: a combined in silico and molecular approach
Lombe, Chipampe Patricia (University of the Western Cape, 2019)2018, the International Agency for Research on Cancer (IARC) estimated that prostate cancer (PCa) was the second leading cause of death in males worldwide. The number of deaths are expected to raise by 50 % in the next ... -
Aptamer selection against GFRa1 for its application in the prognosis of breast cancer
Swartz, Lauren Taryn (University of the Western Cape, 2019)Breast cancer is the second most common cancer amongst South African women. Despite ongoing efforts to combat breast cancer, current prognostic and/or therapeutic monitoring methods are limited since very little improvement, ... -
Biochemical investigation of anti-cancer activity of Tulbaghia violacea
Saibu, Gbemisola Morounke (UWC, 2012)Natural products have been a source of many pharmaceutical drugs and a number of drugs that are currently used in the treatment of cancer are derivatives of compounds originally isolated from natural products. There is ... -
Biogenic synthesis of gold nanoparticles using red and green pear fruit extracts
Barry, Simone Caroline Leslie (University of the Western Cape, 2019)There has been a growing interest in the design of biocompatible and environmentally affable nanoparticles (NPs) among scientists to develop novel and safe biomaterials for use in various biomedical applications. This can ... -
Chemical and biological evaluation of palythoa tuberculosa collected from the red sea
Elbagory, Abdulrahman Mohammed (University of the Western Cape, 2015)A chemical study on the total extract of the zoanthid Palythoa tuberculosa, collected from the Red Sea, resulted in the isolation of seven polyhydroxylated sterols viz: palysterols A-G, six of which are new. Their chemical ... -
Development and characterization of pro-apoptotic drug candidates for anticancer drug discovery
Kanyanda, Stonard Sofiel Elisa (2013)Cancer is one of the leading causes of death worldwide. According to the WHO, cancer accounted for 7.4 million deaths world wide in 2004. The metallo-compound cisplatin has been used for years as an effective antitumor ... -
Development of a receptor targeted nanotherapy using a proapoptotic peptide
Sibuyi, Nicole Remaliah Samantha (University of the Western Cape, 2015)The prevalence of obesity amongst South Africans is alarming, with more than 29% of men and 56% of women considered to be obese. Angiogenesis, a process for development of new blood vessels play a major role in growth and ... -
Development of an aptamer based lateral flow test strip for a diabetes biomarker
Moabelo, Koena Leah (University of the Western Cape, 2019)Diabetes mellitus is one of the major chronic diseases that poses a significant risk to human health globally. Current diagnostics for diabetes are based on blood glucose measurements, which can go unnoticed for years. ... -
The development of nanotechnology-based detection systems for the diagnosis of breast cancer
Drah, Mustafa (University of the Western Cape, 2015)Breast cancer is one of the major causes of death in South Africa. About 1 in 29 South African women are at risk of developing this type of cancer in their lifetime. The global incidence of breast cancer also increases ... -
Development of nanotechnology-based therapeutic approaches to treat HIV
Dodgen, Cleo (University of the Western Cape, 2012)The rapidly expanding field of nanotechnology has been the focus of many biologists with regard to drug delivery. The ability of nanoparticles to enter cellular compartments makes it possible to explore specific treatment ... -
Discriminative eradication of cancer cells using quantum dots functionalised with peptide-directed delivery of a pro-apoptotic peptide
Swartz, Lauren Taryn (2013)The therapeutic goal of cancer treatment is to trigger selective cell death in cancer cells. To eliminate cancerous cells effectively, the anti–cancer drugs must be targeted to the affected cells. However, anti–cancer drugs ... -
Evaluation of cytotoxic activity of gold nanoparticles naturally synthesised from South African indigenous medicinal plant extracts
Mbandezi, Yamkela (University of the Western Cape, 2018)Nanotechnology has emerged as a promising field in the quest to address health conditions. Green nanotechnology is a fairly new branch of nanotechnology, which aims to produce and utilize nanomaterials in a way that is ... -
Green synthesis and characterization of gold nanoparticles from South African plants and their biological evaluations
Elbagory, Abdulrahman Mohammed Mohammed Nagy (University of the Western Cape, 2019)The field of nanotechnology continues to offer solutions for biotechnologists whose target is to improve the quality of life by finding new therapies to combat diseases. Gold nanoparticles (AuNPs) have been showing great ... -
Green synthesis and characterization of silver nanoparticles (AgNPs) from Bulbine frutescens leaf extract and their antimicrobial effects
Lucas, Shakeela (University of the Western Cape, 2020)Combating antimicrobial resistant infections caused by nosocomial pathogens poses a major public health problem globally. The widespread use of broad-spectrum antibiotics for the treatment of wound infections has led to ... -
Identification and characterisation of the role of endozepine in apoptosis induced by ceramide
Meyer, Mervin (University of the Western Cape, 2003)Apoptosis is a form of programmed cell death and is required for the normal development, tissue homeostasis and survival of organisms. The identification of mutations that can lead to alterations in cell death not only ... -
The identification of aptamers against serum biomarkers of human tuberculosis
Martin, Darius Riziki (University of the Western Cape, 2018)Tuberculosis (TB) is a global health problem and rated as the second leading cause of death after HIV/AIDS. Transmission of TB from one person to the next is very rapid in crowded communities. Therefore, it is crucial to ... -
Identification of biomarkers associated with cervical cancer: a combined in silico and molecular approach
Ludaka, Namhla (University of the Western Cape, 2014)Cervical cancer is the leading cause of cancer mortality among black women in South Africa. It is estimated that this disease kills approximately 8 women in South Africa every day. Cervical cancer is caused by the human ... -
Identification of microRNAs as a class of biomarkers for the early diagnosis of prostate cancer : an in silico and molecular approach
Lombe, Chipampe Patricia (University of the Western Cape, 2015)Prostate cancer (PCa) is the second most common form of cancer in men around the world. In many parts of Africa, data on prostate cancer is sparse. This is attributed to poor access to testing and diagnostics. The ... -
The identification of novel regulatory elements in the promoters of heat shock response genes
Ncube, Sifelani (University of the Western Cape, 2010)The main objective of this study was to investigate promoter sequences of putative HSR genes for the presence of unique regulatory elements and modules that might be involved in the regulation of HSR. In order to achieve ... -
In silico and molecular validation of identified putative genes and functional analysis of a N K G2D ligand as a breast cancer biomarkers
Bankole, Habeeb Adebodun (University of the Western Cape, 2015)The current diagnostic, prognostic, predictive and therapeutic monitoring methods used for breast cancer are limited. Thus, research into more specific, sensitive and effective strategies is required. Breast cancer is ...