Browsing South African National Bioinformatics Institute (SANBI) by Title
Now showing items 52-71 of 84
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Identification and characterization of microRNAs and their putative target genes in Anopheles funestus s.s
(2013)The discovery of microRNAs (miRNAs) is one of the most exciting scientific breakthroughs in the last decade. miRNAs are short RNA molecules that do not encode proteins but instead, regulate gene expression. Over the past ... -
Identification and ranking of pervasive secondary structures in positive sense single-stranded ribonucleic acid viral genomes
(University of the Western Cape, 2018)The plasticity of single-stranded viral genomes permits the formation of secondary structures through complementary base-pairing of their component nucleotides. Such structures have been shown to regulate a number of ... -
The identification of biologically important secondary structures in disease-causing RNA viruses
(University of the Western Cape, 2012)Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ... -
The identification of biologically important secondary structures in disease-causing RNA viruses.
(University of the Western Cape, 2012)Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ... -
Identification of coding variants associated with familial systemic lupus erythematosus through whole exome sequencing
(University of the Western Cape, 2016)Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by the production of a wide range of autoantibodies directed against selfantigens. SLE can influence almost any organ system and ... -
Identification of insertion-induced enhancers linked to gene drivers within non-coding DNA using a pipeline for diffuse large b-cell lymphoma H3K27ac ChIP-seq data
(University of the Western Cape, 2022)Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) and incorporates a diverse range of illnesses with varying biology, clinical manifestations, and therapeutic responses. Functional ... -
Incidence and regulatory implications of single Nucleotide polymorphisms among established ovarian cancer genes
(University of the Western Cape, 2009)OVARIAN cancer research focuses on answering important questions related to the disease, determining whether new approaches are feasible to contribute towards improving current treatments or discovering new ones. This study ... -
Integrating regulatory and methylome data for the discovery of clear cell Renal Cell Carcinoma (ccRCC) variants
(University of the Western Cape, 2015)Kidney cancers, of which clear cell renal cell carcinoma comprises an estimated 70%, have been placed amongst the top ten most common cancers in both males and females. With a mortality rate that exceeds 40%, kidney cancer ... -
Investigating genetic diversity and microRNA of Hermetia illucens (the black soldier fly) to breed for mass production of a novel sustainable protein
(University of the Western Cape, 2023)Introduction: A new sustainable source of protein is needed to meet the demands of the growing global population. Insect meal is a suitable replacement, and the black soldier fly (BSF) is the most used insect in industrial ... -
Investigating the structural effect of Raltegravir resistance associated mutations on the South African HIV-1 Integrase subtype C protein structure
(University of the Western Cape, 2020)Background and Aims Human Immunodeficiency Virus (HIV) type 1 group M subtype C (HIV-1C) accounts for nearly half of global HIV-1 infections, with South Africa (SA) being one of the countries with the highest infection ... -
An investigation into the genetic basis of autosomal recessive Osteogenesis imperfecta (OI) III in a South African family of mixed ancestry
(University of the Western Cape, 2022)Osteogenesis Imperfecta (OI) is a rare skeletal dysplasia that is primarily characterized by bone fragility, recurrent fractures, and bone deformities. Over the years there has been an increase in the number of genes ... -
“An investigation into the MicroRNA-gene interactions involved in the pathogenesis of systemic lupus erythematosus”
(University of the Western Cape, 2015)Systemic lupus erythematosus is a chronic, inflammatory disease characterised by the production of autoantibodies which target particularly the nuclear components of multiple cell types throughout the body. MicroRNA’s have ... -
Irradiation induced effects on 6h-SIC
(University of the Western Cape, 2012)The framework agreement in the year 2000 by the international community to launch Generation IV program with 10 nations, to develop safe and reliable nuclear reactors gave rise to the increased interest in the studies of ... -
A knowledgebase of stress reponsive gene regulatory elements in arabidopsis Thaliana
(University of the Western Cape, 2011)Stress responsive genes play a key role in shaping the manner in which plants process and respond to environmental stress. Their gene products are linked to DNA transcription and its consequent translation into a response ... -
Management and analysis of HIV -1 ultra-deep sequence data
(University of the Western Cape, 2014)The continued success of antiretroviral programmes in the treatment of HIV is dependent on access to a cost-effective HIV drug resistance test (HIV-DRT). HIVDRT involves sequencing a fragment of the HIV genome and ... -
Market segmentation and factors affecting stock returns on the JSE
(2008)This study examines the relationship between stock returns and market segmentation. Monthly returns of stocks listed on the JSE from 1997-2007 are analysed using mostly the analytic factor and cluster analysis techniques. ... -
miRNAMatcher: High throughput miRNA discovery using regular expressions obtained via a genetic algorithm
(University of the Western Cape, 2008)In summary there currently exist techniques to discover miRNA however both require many calculations to be performed during the identification limiting their use at a genomic level. Machine learning techniques are currently ... -
Modulation of soybean and maize antioxidant activities by Caffeic acid and nitric oxide under salt stress
(University of the Western Cape, 2012)This study explores the roles of exogenously applied nitric oxide, exogenously applied caffeic acid and salt stress on the antioxidant system in cereal (exemplified by maize) and legume (using soybean as an example) plants ... -
Molecular dynamic simulation studies of the South African HIV-1 Integrase subtype C protein to understand the structural impact of naturally occurring polymorphisms
(University of the Western Cape, 2021)The viral Integrase (IN) protein is an essential enzyme of all known retroviruses, including HIV-1. It is responsible for the insertion of viral DNA into the human genome. It is known that HIV-1 is highly diverse with a ... -
Molecular dynamic simulation studies of the South African HIV-1 Integrase subtype C protein to understand the structural impact of naturally occurring polymorphisms
(University of Western Cape, 2021)The viral Integrase (IN) protein is an essential enzyme of all known retroviruses, including HIV-1. It is responsible for the insertion of viral DNA into the human genome. It is known that HIV-1 is highly diverse with a ...