Browsing Magister Scientiae - MSc (Bioinformatics) by Author "Christoffels, Alan"
Now showing items 1-19 of 19
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A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
Mpondo, Feziwe (2009)Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly ... -
A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
Mpondo, Feziwe (University of the western cape, 2009)Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly ... -
A computational characterisation of the relationship between genome structure and disease genes
Kibler, Tracey Deborah (University of the Western Cape, 2012)This is a pilot study to investigate the relationship between disease gene status and the structure of the human genome with specific reference to regions of recombination. It compares certain characteristics of a control ... -
Data Science techniques for predicting plant genes involved in secondary metabolites production
Muteba, Ben Ilunga (University of the Western Cape, 2018)Plant genome analysis is currently experiencing a boost due to reduced costs associated with the development of next generation sequencing technologies. Knowledge on genetic background can be applied to guide targeted ... -
Development of Open source Laboratory Information Management System (LIMS) For Human Biobanking
Ademuyiwa, Toluwaleke (University of the Western Cape, 2018)Biobanks are collections of biological samples and associated data for future use. The day to day activities in a biobank laboratory is underpinned by a laboratory information management system (LIMS). For example, the ... -
Effects of nucleotide variation on the structure and function of human arylamine n-acetyltransferase 1
Akurugu, Wisdom Alemya (2012)The human arylamine N-acetyltransferase 1 (NAT1) is critical in determining the duration of action and pharmacokinetics of amine-containing drugs such as para-aminosalicylic acid and para-aminobenzoyl glutamate used in ... -
Enabling the processing of bioinformatics workflows where data is located through the use of cloud and container technologies
de Beste, Eugene (University of the Western Cape, 2019)The growing size of raw data and the lack of internet communication technology to keep up with that growth is introducing unique challenges to academic researchers. This is especially true for those residing in rural ... -
Establishing a framework for an African Genome Archive
Southgate, Jamie (University of Western Cape, 2019)The generation of biomedical research data on the African continent is growing, with numerous studies realizing the importance of African genetic diversity in discoveries of human origins and disease susceptibility. The ... -
An evaluation of galaxy and ruffus-scripting workflows system for DNA-seq analysis
Oluwaseun, Ajayi Olabode (University of the Western Cape, 2018)Functional genomics determines the biological functions of genes on a global scale by using large volumes of data obtained through techniques including next-generation sequencing (NGS). The application of NGS in biomedical ... -
An evolutionary genomics approach towards analysis of genes implicated in transmission of trypanosomes between tsetse fly and mammalian host
Mwangi, Sarah Wambui (2009)Human African trypanosomiasis is the world’s third most important parasitic disease affecting human health after malaria and schistosomiaisis. The world health organization estimates approximately 60 million people at risk ... -
Exploring the influence of organisational, environmental, and technological factors on information security policies and compliance at South African higher education institutions: Implications for biomedical research.
Abiodun, Oluwafemi Peter (University of the Western Cape, 2020)Headline reports on data breaches worldwide have resulted in heightened concerns about information security vulnerability. In Africa, South Africa is ranked among the top ‘at-risk’ countries with information security ... -
Exploring the influence of organisational, environmental, and technological factors on information security policies and compliance at South African higher education institutions: Implications for biomedical research.
Abiodun, Oluwafemi Peter (University of Western Cape, 2020)Headline reports on data breaches worldwide have resulted in heightened concerns about information security vulnerability. In Africa, South Africa is ranked among the top ‘at-risk’ countries with information security ... -
The identification of biologically important secondary structures in disease-causing RNA viruses
Tanov, Emil Pavlov (University of the Western Cape, 2012)Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ... -
The identification of biologically important secondary structures in disease-causing RNA viruses.
Tanov, Emil Pavlov (University of the Western Cape, 2012)Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ... -
An investigation into the genetic basis of autosomal recessive Osteogenesis imperfecta (OI) III in a South African family of mixed ancestry
Fernol, Susan Alicia (University of the Western Cape, 2022)Osteogenesis Imperfecta (OI) is a rare skeletal dysplasia that is primarily characterized by bone fragility, recurrent fractures, and bone deformities. Over the years there has been an increase in the number of genes ... -
A knowledgebase of stress reponsive gene regulatory elements in arabidopsis Thaliana
Adam, Muhammed Saleem (University of the Western Cape, 2011)Stress responsive genes play a key role in shaping the manner in which plants process and respond to environmental stress. Their gene products are linked to DNA transcription and its consequent translation into a response ... -
Normalization and statistical methods for crossplatform expression array analysis
Mapiye, Darlington S (University of the Western Cape, 2012)A large volume of gene expression data exists in public repositories like the NCBI’s Gene Expression Omnibus (GEO) and the EBI’s ArrayExpress and a significant opportunity to re-use data in various combinations for novel ... -
Regulatory attributes of the carotenoid biosynthetic pathway in Arabidopsis Thaliana under abiotic stress
Khan, Firdous (University of the Western Cape, 2012)Carotenoids are tetraprenoid (C40) molecules synthesized in plants, fungi, bacteria and algae, via the carotenoid biosynthetic pathway (CBP). Some carotenoids are readily converted to vitamin A (VA) in humans, e.g. ... -
SNP based literature and data retrieval
Veldsman, Werner Pieter (University of the Western Cape, 2016)Reference single nucleotide polymorphism (refSNP) identifiers are used to earmark SNPs in the human genome. These identifiers are often found in variant call format (VCF) files. RefSNPs can be useful to include as terms ...