Search
Now showing items 11-20 of 20
Characterising the Prevalence and Mode of CXCR4 Usage in HIV-1 Group M Subtype C
(University of the Western Cape, 2013)
Determination of CXCR4-usage patterns is essential in establishing suitability
of CCR5 antagonist prescription in HIV-1 infected individuals to
prevent treatment failure. Previous studies have suggested a switch ...
Effects of nucleotide variation on the structure and function of human arylamine n-acetyltransferase 1
(2012)
The human arylamine N-acetyltransferase 1 (NAT1) is critical in determining the duration of action and pharmacokinetics of amine-containing drugs such as para-aminosalicylic acid and para-aminobenzoyl glutamate used in ...
A knowledgebase of stress reponsive gene regulatory elements in arabidopsis Thaliana
(University of the Western Cape, 2011)
Stress responsive genes play a key role in shaping the manner in which plants process and respond to environmental stress. Their gene products are linked to DNA transcription and its consequent translation into a response ...
Development of a simple artificial intelligence method to accurately subtype breast cancers based on gene expression barcodes
(University of the Western Cape, 2018)
INTRODUCTION:
Breast cancer is a highly heterogeneous disease. The complexity of achieving an accurate diagnosis and an effective treatment regimen lies within this heterogeneity. Subtypes of the disease are not simply ...
An evaluation of galaxy and ruffus-scripting workflows system for DNA-seq analysis
(University of the Western Cape, 2018)
Functional genomics determines the biological functions of genes on a global scale by
using large volumes of data obtained through techniques including next-generation
sequencing (NGS). The application of NGS in biomedical ...
Enabling the processing of bioinformatics workflows where data is located through the use of cloud and container technologies
(University of the Western Cape, 2019)
The growing size of raw data and the lack of internet communication technology to
keep up with that growth is introducing unique challenges to academic researchers.
This is especially true for those residing in rural ...
Data Science techniques for predicting plant genes involved in secondary metabolites production
(University of the Western Cape, 2018)
Plant genome analysis is currently experiencing a boost due to reduced costs associated with the
development of next generation sequencing technologies. Knowledge on genetic background can be
applied to guide targeted ...
Establishing a framework for an African Genome Archive
(University of Western Cape, 2019)
The generation of biomedical research data on the African continent is growing, with numerous studies realizing the importance of African genetic diversity in discoveries of human origins and disease susceptibility. The ...
Development of Open source Laboratory Information Management System (LIMS) For Human Biobanking
(University of the Western Cape, 2018)
Biobanks are collections of biological samples and associated data for future use. The day to
day activities in a biobank laboratory is underpinned by a laboratory information management
system (LIMS). For example, the ...
Regulatory attributes of the carotenoid biosynthetic pathway in Arabidopsis Thaliana under abiotic stress
(University of the Western Cape, 2012)
Carotenoids are tetraprenoid (C40) molecules synthesized in plants, fungi, bacteria and algae, via the carotenoid biosynthetic pathway (CBP). Some carotenoids are readily converted to vitamin A (VA) in humans, e.g. ...