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Aptamer selection against GFRa1 for its application in the prognosis of breast cancer
(University of the Western Cape, 2019)
Breast cancer is the second most common cancer amongst South African women. Despite
ongoing efforts to combat breast cancer, current prognostic and/or therapeutic monitoring
methods are limited since very little improvement, ...
Genetic mapping of fruit quality traits in apple (malus x domestica borkh.)
(University of the Western Cape, 2011)
Apple fruit quality is of utmost importance to apple farmers and breeders in the selection and commercialization of new cultivars. Fruit size, colour, texture, firmness and taste are all traits that affect the quality of ...
Diversity of Frankia associated with Morella species of the Cape floristic region of Southern Africa
(University of the Western Cape, 2016)
Frankia is one of two partners in the globally distributed N2-fixing actinorhizal symbiosis between this filamentous soil-dwelling actinomycete and almost 300 species of host plants from eight diverse angiosperm families. ...
Mapping and identification of disease resistance candidate genes in three Malus populations using SSRs, DArT and Infinium SNP markers and Illumina sequencing technology
(University of the Western Cape, 2014)
Apple scab, powdery mildew and woolly apple aphid are a major concern for apple breeders and producers. Control of these diseases is a significant economic and marketing priority for the South African apple industry. ...
Development of nanotechnology-based drug delivery and imaging system to the white adipose tissue vasculature using Wistar Rat Model
(University of the Western Cape, 2013)
Obesity is a complex metabolic disease of excessive fat accumulation. It is a worldwide epidemic affecting billions of people and its pharmacological management is hampered by drug toxicity and undesirable side effects. ...
Tumour specific targeted in vitro theranostics application of fabricated nanostructures in a multi-drug resistant ovarian carcinoma cell line
(University of the Western Cape, 2013)
Ovarian cancer is called the “Silent Killer” as it is often diagnosed in advanced stages of the disease or misdiagnosed which ends with a poor prognostic outcome for the patient. A high rate of disease relapse, a high ...
Identification of miRNA's as specific biomarkers in prostate cancer diagnostics : a combined in silico and molecular approach
(University of the Western Cape, 2015)
There are over 100 different types of cancer, and each of these cancers are classified by the type of cell that it initially affects. For the purpose of this research we will be focussing on prostate cancer (PC). Prostate ...
In silico and molecular validation of identified putative genes and functional analysis of a N K G2D ligand as a breast cancer biomarkers
(University of the Western Cape, 2015)
The current diagnostic, prognostic, predictive and therapeutic monitoring methods
used for breast cancer are limited. Thus, research into more specific, sensitive and
effective strategies is required. Breast cancer is ...
The development of nanotechnology-based detection systems for the diagnosis of breast cancer
(University of the Western Cape, 2015)
Breast cancer is one of the major causes of death in South Africa. About 1 in 29 South African women are at risk of developing this type of cancer in their lifetime. The global incidence of breast cancer also increases ...
A forensic analysis of genetic variation in the Botswana population
(University of the Western cape, 2016)
This thesis has been placed under a long term embargo. Forensic and population genetic parameters were investigated in the Botswana population using autosomal and Y-chromosome short tandem repeat markers. AmpFlSTR Profiler ...