Browsing Magister Scientiae - MSc (Biotechnology) by Author "Meyer, Mervin"
Now showing items 1-14 of 14
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Biogenic synthesis of gold nanoparticles using red and green pear fruit extracts
Barry, Simone Caroline Leslie (University of the Western Cape, 2019)There has been a growing interest in the design of biocompatible and environmentally affable nanoparticles (NPs) among scientists to develop novel and safe biomaterials for use in various biomedical applications. This can ... -
Development of an aptamer based lateral flow test strip for a diabetes biomarker
Moabelo, Koena Leah (University of the Western Cape, 2019)Diabetes mellitus is one of the major chronic diseases that poses a significant risk to human health globally. Current diagnostics for diabetes are based on blood glucose measurements, which can go unnoticed for years. ... -
Development of nanotechnology-based therapeutic approaches to treat HIV
Dodgen, Cleo (University of the Western Cape, 2012)The rapidly expanding field of nanotechnology has been the focus of many biologists with regard to drug delivery. The ability of nanoparticles to enter cellular compartments makes it possible to explore specific treatment ... -
Discriminative eradication of cancer cells using quantum dots functionalised with peptide-directed delivery of a pro-apoptotic peptide
Swartz, Lauren Taryn (2013)The therapeutic goal of cancer treatment is to trigger selective cell death in cancer cells. To eliminate cancerous cells effectively, the anti–cancer drugs must be targeted to the affected cells. However, anti–cancer drugs ... -
Evaluation of cytotoxic activity of gold nanoparticles naturally synthesised from South African indigenous medicinal plant extracts
Mbandezi, Yamkela (University of the Western Cape, 2018)Nanotechnology has emerged as a promising field in the quest to address health conditions. Green nanotechnology is a fairly new branch of nanotechnology, which aims to produce and utilize nanomaterials in a way that is ... -
Green synthesis and characterization of silver nanoparticles (AgNPs) from Bulbine frutescens leaf extract and their antimicrobial effects
Lucas, Shakeela (University of the Western Cape, 2020)Combating antimicrobial resistant infections caused by nosocomial pathogens poses a major public health problem globally. The widespread use of broad-spectrum antibiotics for the treatment of wound infections has led to ... -
The identification of aptamers against serum biomarkers of human tuberculosis
Martin, Darius Riziki (University of the Western Cape, 2018)Tuberculosis (TB) is a global health problem and rated as the second leading cause of death after HIV/AIDS. Transmission of TB from one person to the next is very rapid in crowded communities. Therefore, it is crucial to ... -
Identification of biomarkers associated with cervical cancer: a combined in silico and molecular approach
Ludaka, Namhla (University of the Western Cape, 2014)Cervical cancer is the leading cause of cancer mortality among black women in South Africa. It is estimated that this disease kills approximately 8 women in South Africa every day. Cervical cancer is caused by the human ... -
Identification of microRNAs as a class of biomarkers for the early diagnosis of prostate cancer : an in silico and molecular approach
Lombe, Chipampe Patricia (University of the Western Cape, 2015)Prostate cancer (PCa) is the second most common form of cancer in men around the world. In many parts of Africa, data on prostate cancer is sparse. This is attributed to poor access to testing and diagnostics. The ... -
The identification of novel regulatory elements in the promoters of heat shock response genes
Ncube, Sifelani (University of the Western Cape, 2010)The main objective of this study was to investigate promoter sequences of putative HSR genes for the presence of unique regulatory elements and modules that might be involved in the regulation of HSR. In order to achieve ... -
Peptide functionalised gold nanorods for the selective eradication of target cells using photothermal therapy
Meyer, Miché Desline (University of the Western Cape, 2019)Cancer is one of the leading causes of death, worldwide. Mortality tolls are estimated to reach approximately 13.1 million in 2030. These statistics suggest that current therapeutic strategies are not effective. This is ... -
Proteome signature of breast cancer cells treated with fucoidan
Janodien, Fatima (University of the Western Cape, 2016)Breast cancer is responsible for a large portion of cancer-related deaths. Worldwide, incidence is increasing. Routinely-used treatments for breast cancer are invasive and are associated with a range of side-effects which ... -
Screening of plant-mediated nanoparticles for antifungal activity
de Beer, Irving (University of the Western Cape, 2020)Nanotechnology is spreading rapidly across the world as an extremely powerful technology. Nanoscience and nanotechnology are innovative scientific advancements that have been introduced only in this century. Nanotechnology ... -
Targeted delivery of GFP loaded polymeric nanoparticles to CD4 expressing cells using a CD4 specific aptamer
Mirfin, Tayla Michele (University of the Western Cape, 2020)Human Immunodeficiency Virus (HIV), which is the cause of Acquired Immunodefiency Syndrome (AIDS) is a major global public health issue affecting over 37 million people worldwide and is responsible for claiming over 32 ...