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Exploring the role of the “glycan-shield” of human immunodeficiency virus in susceptibility to, and escape from, broadly neutralising antibodies
(University of the Western Cape, 2018)
The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune
response and a critical vaccine candidate. However, Env is densely glycosylated and
thereby substantially protected from neutralisation. ...