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Now showing items 11-20 of 22
Development of a Hepatitis C Virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
(University of the Western Cape, 2011)
To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ...
Development of a comprehensive annotation and curation framework for analysis of Glossina Morsitans Morsitans expresses sequence tags
(University of the Western Cape, 2011)
This study has successfully identified transcripts differentially expressed in the salivary gland and midgut and provides candidate genes that are critical to response to parasite invasion. Furthermore, an open-source ...
Computational characterization of IRE-regulated genes in Glossina morsitans
(University of Western Cape, 2013)
Blood feeding is a habit exhibited by many insects. Considering the devastating impact
of these insects on human health, it is important to focus research on understanding the
biology behind blood-feeding, disease ...
Prediction of antimicrobial peptides using hyperparameter optimized support vector machines
(University of the Western Cape, 2011)
Antimicrobial peptides (AMPs) play a key role in the innate immune response. They can be ubiquitously found in a wide range of eukaryotes including mammals, amphibians, insects, plants, and protozoa. In lower organisms, ...
Identification and ranking of pervasive secondary structures in positive sense single-stranded ribonucleic acid viral genomes
(University of the Western Cape, 2018)
The plasticity of single-stranded viral genomes permits the formation of secondary structures
through complementary base-pairing of their component nucleotides. Such structures have
been shown to regulate a number of ...
Baobab LIMS: An open source biobank laboratory information management system for resource-limited settings
(University of the Western Cape, 2019)
A laboratory information management system (LIMS) is central to the informatics infrastructure
that underlies biobanking activities. To date, a wide range of commercial and open
source LIMS are available. The decision ...
Computational prediction of host-pathogen protein-protein interactions
(University of the Western Cape, 2017)
Supervised machine learning approaches have been applied successfully to the prediction of protein-protein interactions (PPIs) within a single organism, i.e., intra-species predictions. However, because of the absence of ...
Exploring the role of the “glycan-shield” of human immunodeficiency virus in susceptibility to, and escape from, broadly neutralising antibodies
(University of the Western Cape, 2018)
The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune
response and a critical vaccine candidate. However, Env is densely glycosylated and
thereby substantially protected from neutralisation. ...
Development of a data processing toolkit for the analysis of next-generation sequencing data generated using the primer ID approach
(University of the Western Cape, 2018)
Sequencing an HIV quasispecies with next generation sequencing technologies yields a dataset with
significant amplification bias and errors resulting from both the PCR and sequencing steps. Both the
amplification bias ...
Identification of coding variants associated with familial systemic lupus erythematosus through whole exome sequencing
(University of the Western Cape, 2016)
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease
characterized by the production of a wide range of autoantibodies directed against selfantigens.
SLE can influence almost any organ system and ...