Browsing Faculty of Natural Science by Title
Now showing items 576-595 of 2597
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Development of a data processing toolkit for the analysis of next-generation sequencing data generated using the primer ID approach
(University of the Western Cape, 2018)Sequencing an HIV quasispecies with next generation sequencing technologies yields a dataset with significant amplification bias and errors resulting from both the PCR and sequencing steps. Both the amplification bias ... -
Development of a gas chromatographic technique for the analysis of some groundwater contaminants from fuel leaks and its application in a site-specific study
(University of the Western Cape, 2009)This study focuses on the development of a Direct Aqueous Injection Gas Chromatographic method with Flame Ionization Detection (DAI-GC/FID) for the analysis of MTBE and TBA. The analytical method was then applied in a site ... -
Development of a health management information system using agile software-engineering methods
(2013)The purpose of this thesis is to discuss the development of a web application from scratch. It serves to build a health management information system from basic principles and covers all the software engineering activities ... -
Development of a hepatitis C virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
(2011)To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ... -
Development of a Hepatitis C Virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
(University of the Western Cape, 2011)To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ... -
Development of a high throughput cell-free metagenomic screening platform
(University of the Western Cape, 2016)The estimated 5 × 10³⁰ prokaryotic cells inhabiting our planet sequester some 350–550 Petagrams (1 Pg = 1015 g) of carbon, 85–130 Pg of nitrogen, and 9–14 Pg of phosphorous, making them the largest reservoir of those ... -
Development of a model to predict the cost of management of diabetes mellitus and its complications at Groote Schuur Hospital
(University of the Western Cape, 2012)Diabetes mellitus places a substantial financial burden on the funder for treatment of this disease. This burden is compounded by the development of diabetes mellitus related complications. The cost of management of diabetes ... -
Development of a model to predict the cost of treatment of breast cancer with chemotherapy at Groote Schuur hospital
(University of the Western Cape, 2017)In South Africa, breast cancer dominates other forms of cancer affecting women in both prevalence and mortality rates according to the National Cancer Registry. The incidence and cost of breast cancer have been on the rise ... -
Development of a novel high throughput method for identifying phage-host pairs in an extreme environment
(University of the Western Cape, 2017)There are approximately 10³¹ bacteriophages in the biosphere, outnumbering bacteria 10:1, hence, the dynamic and specific nature of phage-host interactions exerts significant influence on microbial communities. Bacteriophages ... -
Development of a plum chromosome doubling method and proteomics and biochemical characterization
(University of the Western Cape, 2015)Chromosome doubling has become an important tool in breeding programmes as it offers the ability of introducing novel traits into existing plants. Doubled haploid plants are highly valued by both consumers and breeders as ... -
Development of a receptor targeted nanotherapy using a proapoptotic peptide
(University of the Western Cape, 2015)The prevalence of obesity amongst South Africans is alarming, with more than 29% of men and 56% of women considered to be obese. Angiogenesis, a process for development of new blood vessels play a major role in growth and ... -
Development of a reporter system for the analysis of xylophilus ampelinus type III secreted effectors
(University of the Western Cape, 2014)Xylophilus ampelinus, the causal agent of bacterial blight and canker of grapevines, has long been a threat to the table grape industry in the Western Cape, leading to severe economic losses due to the reduced productivity ... -
The development of a sars-cov-2 pseudoparticle assay for the detection of neutralizing antibodies in sera from covid-19 patients
(University of the Western Cape, 2024)The COVID-19 pandemic has caused devastating effects on the global socio-economic landscape. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, and infections have led to ... -
Development of a simple artificial intelligence method to accurately subtype breast cancers based on gene expression barcodes
(University of the Western Cape, 2018)INTRODUCTION: Breast cancer is a highly heterogeneous disease. The complexity of achieving an accurate diagnosis and an effective treatment regimen lies within this heterogeneity. Subtypes of the disease are not simply ... -
The development of a single nucleotide polymorphism database for forensic identification of specified physical traits
(University of the Western Cape, 2009)Many Single Nucleotide Polymorphisms (SNPs) found in coding or regulatory regions within the human genome lead to phenotypic differences that make prediction of physical appearance, based on genetic analysis, potentially ... -
Development of a small-scale electro-chlorination system for rural water supplies
(2010)To address the urgent need for safe potable water in South Africa’s rural areas, sustainable systems for water disinfection at the village-scale of operation are required.In this thesis, the development of a small-scale ... -
The development of a woman’s health handbook in the Western Cape
(2010)Background:The Project reported on in this thesis took place between 2003 and 2006 and focused on the problem of high rates of low birth weight in the West Coast /Winelands area of the Western Cape Province, South Africa. ... -
Development of amperometric biosensor with cyclopentadienylruthenium (II) thiolato schiff base self-assembled monolayer (SAM) on gold
(University of the Western Cape, 2007)A novel cyclopentadienylruthenium(II) thiolato Schiff base, [Ru(SC6H4NC(H)C6H4OCH2CH2SMe)(η5-C2H5]2 was synthesized and deposited as a selfassembled monolayer (SAM) on a gold electrode. Effective electronic communication ... -
Development of an actinobacteria based in vitro transcription and translation systems
(University of the Western Cape, 2015)Heterologous metagenomic screening strategies have relied largely on the construction of DNA libraries and screening in Escherichia coli to access novel enzymes. There is an increased demand for the identification of novel ... -
Development of an aptamer based lateral flow test strip for a diabetes biomarker
(University of the Western Cape, 2019)Diabetes mellitus is one of the major chronic diseases that poses a significant risk to human health globally. Current diagnostics for diabetes are based on blood glucose measurements, which can go unnoticed for years. ...