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Computational analysis of multi-omic data for the elucidation of molecular mechanisms of neuroblastoma
(University of Western Cape, 2021)
Neuroblastoma is the most common extracranial solid tumor in childhood. The survival rates of patients with neuroblastoma, especially those in the high-risk category, are still low despite varied therapies. The detailed ...
Exploration of the training/educational background and the roles of regulatory affairs associates/officers in selected South African based pharmaceutical companies in Gauteng province
(University of Western Cape, 2021)
Regulatory Affairs (RA), within the pharmaceutical business, could be a profession that covers different registration parameters of a pharmaceutical product. This is a profession that was developed to protect the public ...
Investigating the effects of nutrients and chlorophyll concentrations on the water quality of the Nuwejaars River, Cape Agulhas, Western Cape
(University of Western Cape, 2021)
The Nuwejaars River flows into the largest natural freshwater lake in South Africa, Soetendalsvlei, which relies on and interacts with the Nuwejaars River. Therefore, the water quality of the Nuwejaars River plays a role ...
The paracrine effect of normoxic and hypoxic cancer secretions on blood-brain barrier endothelial cells
(University of the Western Cape, 2022)
Cancer is the most common leading cause of death worldwide. Glioblastoma and breast cancer are the most aggressive solid tumour. The survival rate of these tumours depends on their ability to progress and spread. These ...
Analysis and robust simulation of mathematical models of HIV and Leishmaniasis co-infection
(University of the Western Cape, 2022)
The purpose of this thesis is the theoretical and numerical study of epidemiological
models of Visceral Leishmaniasis (VL) and human immunode ciency virus (HIV) coinfection.
We study these models theoretically and design ...
Next generation sequencing approaches for novel gene discovery in South African Parkinson’s disease families
(University of the Western Cape, 2022)
In the last decade, next-generation sequencing (NGS) approaches have revolutionised
the study of human genomics, particularly aiding the understanding of genetic diseases. Parkinson’s
disease (PD) is a complex neurodegenerative ...
Synthesis and evaluation of metformin derivatives for anti-diabetes
(University of the Western Cape, 2022)
Type 2 diabetes mellitus (T2DM) is a significant public health crisis and is placed amongst the top ten leading causes of death worldwide. Metformin is the first-line drug used to treat T2DM, which is mainly attributed to ...
Investigation of common deficiencies observed in scientific assessments and the implementation of a new robust review pathway, the risk-based assessment approach, by the South African Health Regulatory Authority, SAHPRA
(University of the Western Cape, 2022)
The main objective of this study is to improve patient access to medicines. The research is two-fold, the
first component promotes transparency between the South African Health Products Regulatory
Authority (SAHPRA), ...
The determinants of under-five child mortality in the state of Palestine and Malawi: A comparative study
(University of the Western Cape, 2022)
Mortality is one of the significant vital events for which a government collects data, especially
child mortality, because it is one of the contributing indicators that are used to assess the
wellbeing of a nation. ...
Electroanalysis of sars-cov-2 specific igg and igm antibodies at microfluidic paper-based devices
(University of the Western Cape, 2022)
The Covid-19 pandemic has taken the world by storm. The infectious disease, SARS-CoV-2,
was caused by a newly found virus of the corona family. With over 6 million deaths worldwide,
it is evident that the SARS-CoV-2 virus ...