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Molecular dynamic simulation studies of the South African HIV-1 Integrase subtype C protein to understand the structural impact of naturally occurring polymorphisms
(University of the Western Cape, 2021)
The viral Integrase (IN) protein is an essential enzyme of all known retroviruses, including HIV-1. It is responsible for the insertion of viral DNA into the human genome. It is known that HIV-1 is highly diverse with a ...
Targeted delivery of GFP loaded polymeric nanoparticles to CD4 expressing cells using a CD4 specific aptamer
(University of the Western Cape, 2020)
Human Immunodeficiency Virus (HIV), which is the cause of Acquired Immunodefiency Syndrome (AIDS) is a major global public health issue affecting over 37 million people worldwide and is responsible for claiming over 32 ...
The use of ultrasonography for the early detection of cardiovascular risk in adolescents
(University of the Western Cape, 2022)
Cardiovascular disease (CVD) is the major cause of mortality and morbidity globally and is the leading cause of death in South Africa second to HIV/AIDS. CVD is on the rise not only in adults but also in children. The ...