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The effect of co-crystallization and polymorphism on the physicochemical properties of amoxicillin tri-hydrate
(University of the Western Cape, 2013)
Many active pharmaceutical ingredients (APIs) have poor physicochemical properties such as solubility, dissolution and chemical stability. Several strategies are used to enhance and improve these properties of the API. ...
Proteomic and SNP analysis of the Cadherin 10 type-II (CDH10) gene, in the South African autistic population
(University of the Western Cape, 2013)
Autism or autism spectrum disorder (ASD) is a very diverse neurological disorder that manifests specifically in children and infants between the ages of two to three years of age. An individual suffering is deemed as ...
Development of nanotechnology-based drug delivery and imaging system to the white adipose tissue vasculature using Wistar Rat Model
(University of the Western Cape, 2013)
Obesity is a complex metabolic disease of excessive fat accumulation. It is a worldwide epidemic affecting billions of people and its pharmacological management is hampered by drug toxicity and undesirable side effects. ...
Graphene-modified pencil graphite bismuth-film electrodes for the determination of heavy metals in water samples using anodic stripping voltammetry
(University of the Western Cape, 2013)
Electrochemical platforms were developed based on pencil graphite electrodes (PGEs) modified with electrochemically deposited graphene (EG) sheets and Nafion-graphene (NG) nanocomposites in conjunction with an in situ ...
Tumour specific targeted in vitro theranostics application of fabricated nanostructures in a multi-drug resistant ovarian carcinoma cell line
(University of the Western Cape, 2013)
Ovarian cancer is called the “Silent Killer” as it is often diagnosed in advanced stages of the disease or misdiagnosed which ends with a poor prognostic outcome for the patient. A high rate of disease relapse, a high ...
Laser drilling of metals and glass using zero-order bessel beams
(University of the Western Cape, 2013)
This dissertation consists of two main sections. The first section focuses on generating zero order Bessel beams using axicons. An axicon with an opening angle y = 5⁰ was illuminated with a Gaussian beam of width ω₀ = 1.67 ...
Supercapacitor electrode materials based on nanostructured conducting polymers and metal oxides
(University of the Western Cape, 2013)
Supercapacitors are charge-storage devices. Compared to batteries, they have higher power density, more excellent reversibility and longer cycle life. Therefore, supercapacitors have played an increasingly important role ...
Studies on the diversity and spatial distribution of deep-water sponges along the west and south coasts of South Africa
(University of the Western Cape, 2013)
This thesis explores the diversity, spatial patterns and community structure for the sponges (Porifera) along the west and south coasts of South Africa. Species collected were identified to the lowest level of lowest ...
Fabrication of type-I indium-based near-infrared emitting quantum dots for biological imaging applications
(University of the Western Cape, 2013)
Semiconductor nanocrystals or quantum dots (QDs) are fluorescent nanometer-sized particles
which have physical dimensions that are smaller than the excitonic Bohr radius, large surface
area-to-volume ratios, broad ...
Characterization of joints in the Keimoes suite with respect to Namaqua deformation events
(University of the Western Cape, 2013)
The Keimoes Suite is a group of poorly defined granitoids that characterize the Namaqua Front and Foreland zones. There is a lack of knowledge on its content and distribution. A significant amount of work has been done on ...