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The effect of nicotine and prostaglandin A2 on the lung cancer cell line NCI-H157
(2009)
Lung cancer is the most common fatal cancer in terms of both incidence and mortality in the world. The most important cause of lung cancer is exposure to
tobacco smoke through active or passive smoking. Nicotine which is ...
Screening of natural products and alkylating agents for antineoplastic activity
(2007)
Apoptosis is a process in which a cell programmes its own death. It is a highly organized physiological mechanism in which injured or damaged cells are destroyed. Apart from physiological stimuli however, exogenous factors ...
Investigation into the role of DWNN in cell death
(University of the Western Cape, 2004)
Many genes are activated to influence the self-destruction programme of the cell. This programme entails synchronised instigation and implementation of numerous subprograms. The arrival of gene targeting aided in the ...
Functional analysis of the mouse RBBP6 gene using Interference RNA
(University of the Western Cape, 2007)
The aim of this thesis was to investigate the cellular role of the mouse RBBP6 gene using the interference RNA (RNAi) gene targeting technology and also to understand the relevance of two promoters for the RBBP6 gene.
Identification and characterisation of a novel gene, DWNN, isolated from promoter-trapped Chinese hamster ovary cells
(University of the Western Cape, 2005)
The process of cytotoxic T lymphocyte (CTL) killing involves the recognition and destruction of foreign antigens by cytotoxic T cells and is of crucial importance to the defence of the organism against viral infections. ...
Apoptotic markers in ejaculated human spermatozoa
(University of the Western Cape, 2005)
The role of male germ cell death in spermatogenesis is an important one as it removes dysfunctional or genetically damaged germ cells and is necessary to maintain an optimal germ cell to Sertoli cell ratio. The formation ...
A yeast 2-hybrid screen to identify and characterize interaction partners of the cancer associated protein Retinoblastoma binding protein 6
(University of the Western Cape, 2009)
Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa protein that is implicated in mRNA processing and ubiquitination functions and has been shown to be highly up-regulated in a number of cancers. In humans and mice, RBBP6 ...