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Purification and characterisation of plasmodium falciparum Hypoxanthine phosphoribosyltransferase
(University of the Western Cape, 2007)
Malaria remains the most important parasitic disease worldwide. It is estimated that over 500 million infections and more that 2.7 million deaths arising from malaria occur each year. Most (90%) of the infections occur in ...
The development of a single nucleotide polymorphism database for forensic identification of specified physical traits
(University of the Western Cape, 2009)
Many Single Nucleotide Polymorphisms (SNPs) found in coding or regulatory regions within the human genome lead to phenotypic differences that make prediction of physical appearance, based on genetic analysis, potentially ...
Computational verification of published human mutations
(University of the Western Cape, 2008)
The completion of the Human Genome Project, a remarkable feat by any measure, has provided over three billion bases of reference nucleotides for comparative studies. The next, and perhaps more challenging step is to analyse ...
Concept Based Knowledge Discovery from Biomedical Literature
(University of the Western Cape, 2009)
This thesis describes and introduces novel methods for knowledge discovery and presents a software system that is able to extract information from biomedical literature, review interesting connections between various ...
A bioinfonnatics approach to the study of the transcriptional regulation of AMPA Glutamate receptors (GRIAs) and genes whose expression are co-regulated with GRIAs
(University of the Western Cape, 2009)
It was postulated that each gene has three main sets of transcriptional elements: one which is gene-specific, one which is family-specific, and a third which is tissue-specific. The starting hypothesis for this project had ...
Development and implementation of ontology-based systems for mammalian gene expression profiling
(University of the Western Cape, 2009)
The use of ontologies in the mapping of gene expression events provides an
effective and comparable method to determine the expression profile of an entire
genome across a large collection of experiments derived from ...