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Computational analysis of multi-omic data for the elucidation of molecular mechanisms of neuroblastoma
(University of Western Cape, 2021)
Neuroblastoma is the most common extracranial solid tumor in childhood. The survival rates of patients with neuroblastoma, especially those in the high-risk category, are still low despite varied therapies. The detailed ...
DNA metabarcoding for the identification of species within vegetarian food samples
(University of the Western Cape, 2021)
Aims DNA metabarcoding has recently emerged as a valuable supplementary tool to ensure food authenticity within the global food market. However, it is widely known that highly processed food samples are one of DNA ...
Reconstruction of gene regulatory networks of inflammation-associated genes in different clinical stages of diffuse large B-cell lymphoma
(University of the Western Cape, 2022)
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy
that is driven by complex gene regulatory networks (GRNs). Numerous genes exert
distinct effects on the progression and therapeutic outcome of DLBCL. ...
A deep learning approach to predicting potential virus species crossover using convolutional neural networks and viral protein sequence patterns
(University of the Western Cape, 2022)
Medical science has made substantial progress toward diagnosing, understanding the pathogenesis, and treating various causative agents of infectious disease; however, novel microbial pathogens continue to emerge, and ...
Homology modelling and characterization of three-dimensional (3d) protein structures of selected variants of cyp3a4
(University of the Western Cape, 2022)
The efficacy and toxicity of several drugs and prodrugs are influenced by the interindividual
genetic variations in drug-metabolising enzymes. Cytochrome P450
enzymes constitute the major metabolising enzymes in humans. ...
An investigation into the genetic basis of autosomal recessive Osteogenesis imperfecta (OI) III in a South African family of mixed ancestry
(University of the Western Cape, 2022)
Osteogenesis Imperfecta (OI) is a rare skeletal dysplasia that is primarily characterized by bone fragility, recurrent fractures, and bone deformities. Over the years there has been an increase in the number of genes ...
Next generation sequencing approaches for novel gene discovery in South African Parkinson’s disease families
(University of the Western Cape, 2022)
In the last decade, next-generation sequencing (NGS) approaches have revolutionised
the study of human genomics, particularly aiding the understanding of genetic diseases. Parkinson’s
disease (PD) is a complex neurodegenerative ...
Development of an operon detection algorithm to analyze gene regulation in drug resistant Mycobacterium tuberculosis
(University of the Western Cape, 2022)
In prokaryotes, operon structures often form to allow microorganisms to respond rapidly and efficiently to changing environmental conditions. Operons are sets of neighbouring genes which are co-regulated and co-transcribed. ...
Novel genomic biomarkers for pediatric and adult acute myeloid leukemia
(University of the Western Cape, 2023)
Acute myeloid leukemia (AML) is a heterogeneous type of blood cancer that affects individuals of all ages. AML patients are categorized into favorable, intermediate, and adverse risks based on patients' genomic features ...