Department of Medical BioSciences
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The role of the glutathione system in regulating the levels of ROS neutralisation in the endothelial cells of the blood-brain barrier
(University of the Western Cape, 2017)Brain endothelial cell types are frequently used as in vitro models to study the blood-brain barrier (BBB). Oxidative stress (OS) has been reported numerous times to cause BBB dysfunction which is crucial to the initiation ... -
OnabotulinumtoxinA Injection for Glabellar Frown Lines as an Adjunctive Treatment for Depression
(University of the Western Cape, 2017)Depression is one of the most prevalent mental disorders worldwide. Sadness, fear and anger which are considered as negative emotions and are common in depression are coupled with the stimulation of the Corrugator supercilli ... -
The antifungal effect of Salvadora persica and Euclea natalensis on Candida isolates from Libyan patients with type 2 Diabetes mellitus.
(University of the Western Cape, 2018)Improved oral hygiene plays a vital role on quality of health and well-being of diabetic patients. Poor oral health leads to an increased incidence of oral diseases, particularly oral candidiasis. The emergence and global ... -
Radiosensitization effects of gold nanoparticles in proton therapy
(University of the Western Cape, 2017)Despite recent advances in radiotherapy, some tumours have shown to be resistant to treatment and patients still experience long term side effects. Gold nanoparticles (AuNPs) have been identified as effective radiosensitizers ... -
Effects of Libyan traditional plants on the reproductive system of male and female rats
(University of the Western Cape, 2015)In different parts of the world, medicinal plants have demonstrated a lot of health benefits to mankind and remains an important source for the discovery of new bio-active compounds. Libya is a typical example of a country ... -
Evaluation of standard and development of new sperm function tests in selected primate species
(University of the Western Cape, 2017)Male infertility in humans has increased in the last few decades and could be as high as 40%, while up to 50% of these men have ''unexplained'' (idiopathic) infertility. Although newly developed molecular techniques have ... -
Medicinal uses of Galenia africana: A study of the antimicrobial, antifungal and anticancer properties
(University of the Western Cape, 2017)Over the years, microorganisms have become resistant to commonly used antimicrobial agents leading to multidrug resistance. This is believed to occur even with new classes of therapeutic agents thus creating a challenge ... -
The effects of maternal nicotine exposure during pregnancy or lactation on hypertension of the offspring
(University of the Western Cape, 2016)Blood pressure and heart rate is known to increase during smoking. These effects are specifically associated with nicotine while the other components of tobacco smoke seem to be of minor importance. It is becoming increasingly ... -
The interaction between 6 MV X-rays and p(66)/Be neutrons with spherical gold nanoparticles to induce cellular damage
(University of the Western Cape, 2016)Despite the advances in therapies such as chemotherapy and radiotherapy, tumours have been shown to be resistant to the treatments. Gold nanoparticles (AuNPs) have been recognized as effective radiosensitizers of low energy ... -
Investigating effects of aqueous root extract of Mondia whitei on sperm functionality
(University of the Western Cape, 2016)Introduction: Mondia whitei commonly known as "White Ginger" is a highly acclaimed medicinal plant that is extensively used across Africa. M. whitei is used as treatment for sexual dysfunction and is considered to be an ... -
The possible effect of Hypoxis hemerocalledia (African potato) on blood glucose levels : an in vitro study
(University of the Western Cape, 2015)The plant Hypoxis hemerocallidea, also known as the African potato, is commonly used as a traditional medicine to treat diabetes in South Africa. The mechanism by which it lowers blood glucose levels is not known. The ... -
Semen characteristics of free-ranging African elephants (Loxodonta africana) and Southern white rhinoceros (Ceratotherium simum simum) using Computer-aided sperm analysis, Electron microscopy and Genomics as diagnostic tools
(University of the Western Cape, 2016)The survival of free-ranging (in situ) African elephant and Southern white rhinoceros populations are currently being challenged on a daily basis in Africa. Reproductive health is considered a vital component of species ... -
Effects of Libyan traditional plants on the reproductive system of male and female rats
(University of the Western cape, 2015)In different parts of the world, medicinal plants have demonstrated a lot of health benefits to mankind and remains an important source for the discovery of new bio-active compounds. Libya is a typical example of a country ... -
The effect of Libyan date palm pollen and flax seed on general and specific properties of testicular and breast cancer cells
(University of the Western cape, 2016)There is increasing concern worldwide by researchers with regards to the assessing of safety and therapeutic consumption of the plants used in traditional medicine. Date palm pollen (DPP) and flax seed have been used ... -
Cloning and expression of human cyclophilin A and its interaction with human coronavirus NL63 nucleocapsid protein
(University of the Western Cape, 2011)Coronaviridae family is composed of a number of ribonucleic acid (RNA)-containing viruses currently classified into two genera, the coronavirus and torovirus. The family is classified together with the Arteviridae in the ... -
The association between environmental exposures during childhood and the subsequent development of crohn's disease in the Western Cape
(University of the Western Cape, 2015)Background: A subtype of inflammatory bowel disease, Crohn’s disease is thought to represent a complex interaction between environmental factors, a defective immune system, the gastrointestinal microbiome and genetic ... -
Bionomics of vector-borne diseases in sites adjacent to lakes Victoria and Baringo in Kenya
(University of the Western Cape, 2016)Bionomics of vector-borne pathogens (VBPs) is a complex phenomenon that involves understanding the ecology of arthropod borne pathogens and vertebrate hosts potentially involved in their transmission cycles. Investigations ... -
An in vitro investigation of the effects of camellia sinensis and aspalathus linearis on benign (RPWE 1) and malignant (LNCaP) prostate cell lines
(University of the Western Cape, 2015)The prostate is prone to three pathological processes that include inflammation, benign prostate hyperplasia (BPH) and tumors. According to the center for Disease and Control 1999-2012 report, prostate cancer is the second ... -
Investigation of some possible mechanisms involved in the anticonvulsant activity of Tulbaghia violacea harv
(University of the Western Cape, 2015)Even though Tulbaghia violacea has been used to treat and manage epilepsy in South Africa by traditional medicine practitioners, no evidence in any literature has shown any scientific scrutiny of the effectiveness of the ... -
Investigations on the effects of Typha capensis on male reproductive functions
(University of the Western Cape, 2016)Introduction: Typha capensis, commonly referred to as bulrush also called "love reed'' growing in Southern Africa's wetlands, is one of South Africa indigenous medicinal plants that are traditionally used to treat male ...
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