Department of Medical BioSciences
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Formulation and evaluation of the biocompatibility of chitosan-dextran nanoparticles using a blood-brain barrier model
(University of the Western Cape, 2018)Central nervous system (CNS) infections are a therapeutic challenge. This is partly due to insufficient drug penetration across the blood-brain barrier (BBB). The BBB is a specialized, highly selective, metabolically active ... -
The role of arylamine N-acetyltransferase 1 (NAT1) in the clinical therapy of tuberculosis
(University of the Western Cape, 2017)Despite attempts to develop new drugs to reduce the worldwide mortality rate attributable to tuberculosis (TB), the illness remains a threat. Isoniazid (INH) has been used as a frontline drug for decades. However, several ... -
The effect of rooibos and green tea flavnoids on the physiology of TM3 Leydig cells
(University of the Western Cape, 2018)Camellia sinensis (C.sinesis) and Aspalathus linearis (A.linearis) are popular beverages consumed in many countries. Consumption of these plants may protect against cardiovascular disease, neurodegenerative disease, various ... -
Investigating the anti-cancer activity of novel phenothiazines in glioblastoma
(University of the Western Cape, 2018)Glioblastoma multiforme (GBM) remains the most malignant of all primary adult brain tumours. It is a highly invasive and vascularized neoplasm with limited treatment options and very low survival rate. GBM tumours are ... -
The in vitro effects of heavy metals and nanoparticles on the immune system
(University of the Western Cape, 2017)Heavy metals and nanoparticles may be released into the environment due to their use and applications. Sources of high, toxic metal concentrations may result from leachates from hazardous waste sites, discharge from ... -
The use of whole blood cell cultures as a model for assessing the effects of SeptilinTM on the immune system.
(University of the Western Cape, 2017)In the past three decades there has been a huge increase in the use of herbal medicine globally. The active principles of these herbal medicines are mostly unknown with supportive evidence for safety and efficacy very ... -
Hyperglycinemia in captive-bred vervet monkeys with cataracts: genetic dynamics and associations
(University of the Western Cape, 2017)A small percentage (8%) of the captive-bred vervet monkeys (Chlorocebus aethiops) maintained at Primate Unit and Delft Animal Centre (PUDAC) of the South African Medical Research Council (SAMRC) were found to have high ... -
The effects of selective inhibitors of n-glycosylation and endoplasmic reticulum stress inducers on the expression of neuroblastoma drug resistance
(University of the Western Cape, 2017)Neuroblastoma (NB) represents 8-10% of all childhood tumours and accounts for approximately 15% of all cancer-related deaths in the paediatric population. Approximately half of newly diagnosed children with this tumour ... -
Examination of the biocompatibility and anti-microbial activity of coated dental implants
(University of the Western Cape, 2017)Teeth are important to all people for chewing, speech and aesthetics. Tooth decay, periodontal disease and physical trauma or injuries are the main causes of tooth loss. There are different forms of treatment for tooth ... -
Potamonautes spp. As a bioindicator for oestrogenic endocrine disrupting chemicals
(University of the Western Cape, 2017)Environmental pollutants, such as endocrine disrupting chemicals (EDCs), are a health concern as they can adversely affect animal health by interfering with the normal function of hormones. Oestrogenic EDCs can cause ... -
The Generation of Antibodies against Human Coronavirus NL63 (HCoV-NL63) Nucleocapsid Protein
(University of the Western Cape, 2017)Coronaviruses (CoVs) are enveloped viruses composed of single-stranded, positive sense RNA viruses with the largest viral genomes among RNA viruses (27-33 kb). In 2004, human coronavirus NL63 (HCoV-NL63) was discovered by ... -
The effects of selective inhibitors of N-Glycosylation and Endoplasmic Reticulum stress inducers on Neuroblastoma cell proliferation and Apoptosis
(University of the Western Cape, 2017)Among all childhood cancers diagnosed, neuroblastoma (NB) is the most prevalent during infancy. In patients younger than 15 years, it accounts for more than 7% of malignancies and about 15% of all paediatric mortalities. ... -
Effects of Fucoidan and Chemotherapeutic agent combinations on Malignant and Non-Malignant breast cell lines
(University of the Western Cape, 2017)Breast cancer is currently one of the most common malignancies in women. Fucoidan (FUC) is a natural polysaccharide with anticancer properties. Despite a number of in vitro and in vivo studies reporting the efficacy of ... -
The use of whole blood cell cultures as a model for assessing the effects of Septilin on the immune system
(University of the Western Cape, 2017)In the past three decades there has been a huge increase in the use of herbal medicine globally. The active principles of these herbal medicines are mostly unknown with supportive evidence for safety and efficacy very ... -
The evaluation of the cardioprotective effects of Olea containing liposomes
(University of the Western Cape, 2017)High levels of free oxygen radicals, induced by many biological or environmental factors, result in damage and dysfunction of the mitochondria which causes cardiovascular and other diseases. Cardiotherapies employing antioxidants ... -
The assessment of Namibian water resources for endocrine disruptors
(University of the Western Cape, 2018)Namibia is the driest sub-Saharan country in Africa and it is characterised by low and variable rainfall. As a result, potable water in this mostly semi-arid country is considered an extremely valuable resource. Given ... -
The role of the glutathione system in regulating the levels of ROS neutralisation in the endothelial cells of the blood-brain barrier
(University of the Western Cape, 2017)Brain endothelial cell types are frequently used as in vitro models to study the blood-brain barrier (BBB). Oxidative stress (OS) has been reported numerous times to cause BBB dysfunction which is crucial to the initiation ... -
OnabotulinumtoxinA Injection for Glabellar Frown Lines as an Adjunctive Treatment for Depression
(University of the Western Cape, 2017)Depression is one of the most prevalent mental disorders worldwide. Sadness, fear and anger which are considered as negative emotions and are common in depression are coupled with the stimulation of the Corrugator supercilli ... -
The antifungal effect of Salvadora persica and Euclea natalensis on Candida isolates from Libyan patients with type 2 Diabetes mellitus.
(University of the Western Cape, 2018)Improved oral hygiene plays a vital role on quality of health and well-being of diabetic patients. Poor oral health leads to an increased incidence of oral diseases, particularly oral candidiasis. The emergence and global ... -
Radiosensitization effects of gold nanoparticles in proton therapy
(University of the Western Cape, 2017)Despite recent advances in radiotherapy, some tumours have shown to be resistant to treatment and patients still experience long term side effects. Gold nanoparticles (AuNPs) have been identified as effective radiosensitizers ...
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