Department of Medical BioSciences
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The effects of PGA2 on cell cycle progression in oesophageal carcinoma cells
(University of the Western Cape, 2003)The molecular mechanisms causing anti-mitotic and cytotoxic effects of prostaglandin .A2 [PGA2 (CzoHroOa)] treatment of human oesophageal carcinoma (WHCO3) cells were investigated. WHCO3 cells, incubated with cytotoxic ... -
Synthesis and characterization of magneto-electric nanoparticles for delivery of antituberculosis drugs across the blood-brain barrier
(University of the Western Cape, 2022)The anatomical structure of the brain at the blood–brain barrier (BBB) creates a limitation for the movement of drugs into the central nervous system (CNS). Although anti-infective drugs effective against Mycobacterium ... -
Investigation of the in vitro antidiabetic and neuroprotective effects of selected Helichrysum species against high monosaccharide-induced toxicity
(University of the Western Cape, 2022)Chronic hyperglycaemia (glucotoxicity), a common complication in diabetes mellitus (DM), is known to cause cognitive decline in some of these patients, often affecting their overall quality of life. Some medicinal plants ... -
An evaluation of the biopesticidal characteristics of Helichrysum marifolium and Helichrysum patulum and their effects on animal metabolism
(University of the Western Cape, 2002)There ate a number of pesticides that are suspected to be endocrine disrupters' Many of these pesticides are man-made. Endocrine disrupters are chemicals that can lead to an increase in birth defects, sexual abnormalities, ... -
Proteome profiling as tool to determine the effectiveness of traditional Africa therapies for Type 2 diabetes mellitus
(University of the Western Cape, 2022)Type 2 diabetes mellitus (T2DM) involves multiple organ dysfunction accompanied by a chronic inflammatory state and oxidative stress resulting from a combination of factors such as hyperglycaemia and dyslipidaemia. Although ... -
''A molecular investigation of the prevalence of suspected periodontopathogens and their association with preterm birth.''
(University of the Western Cape, 2010)More than 20 million infants in the world (15.5 % of all births) are born with low birth weight. Ninety-five oZ of them are in developing countries. Oral colonization of Gramnegative anaerobes has been implicated as a risk ... -
lnvestigations into the cancer modulating properties of Aspalathus linearis (Rooibos), Cyclopia intermedia (Honeybush) and Sutherlandia frutescens (Cancer bush) in oesophagea! carci nogenesis
(University of the Western Cape, 2007)This thesis contains scientific evidence on the anticancer properties of two unique South African herbal teas, rooibos and honeybush, and the herbal plant Sutherlandia frutescens (cancer bush) using an in vivo oesophageal ... -
An assessment of Carpobrotus acinaciformis and Cissampelos capensis as potential antimicrobial agents and their effects on animal metabolism
(University of the Western Cape, 2002)The definition of a medicinal plant (as formulated by the WHO) is a plant that consists of either one or more plant parts with therapeutic properties that can be used in the development of drugs (sofowora lg82). Various ... -
An evaluation of the biopesticidal characteristics of Helichrysum marifolium and Hetichrysum patulum and their effects on animal metabolism
(University of the Western Cape, 2002)There ate a number of pesticides that are suspected to be endocrine disrupters' Many of these pesticides are man-made. Endocrine disrupters are chemicals that can lead to an increase in birth defects, sexual abnormalities, ... -
The use of ultrasonography for the early detection of cardiovascular risk in adolescents
(University of the Western Cape, 2022)Cardiovascular disease (CVD) is the major cause of mortality and morbidity globally and is the leading cause of death in South Africa second to HIV/AIDS. CVD is on the rise not only in adults but also in children. The ... -
The development of targeting nanosystems for the treatment of glioblastoma and neuroblastoma tumours
(University of the Western Cape, 2022)Chlorotoxin (CTX) peptide selectively targets glioblastoma multiforme (GB) and neuroblastoma (NB) and has excellent blood-brain barrier permeability. Therefore, CTX is a promising targeting molecule for nanoparticle (NP) ... -
The prevalence, risk factors and serotypes of GBS in Libyan women at labour and the rate of vertical transmission of GBS from mother to infant
(University of the Western Cape, 2022)Group B Streptococcus (GBS) also known as Streptococcus agalactia, is one of the most important causes of serious neonatal infections. Early detection of GBS colonisation in the mother is thus of primary importance to ... -
Investigating the relationship between iron deficiency and depressive symptoms in relation to the body compositions of students residing in the Western Cape
(University of the Western Cape, 2022)Iron deficiency is the consequence of a prolonged diminished iron balance, whereby iron stores are no longer sufficient to meet the requirements of regular iron turnover. It is the most ubiquitous single nutrient deficiency, ... -
Sperm function in different human sperm subpopulations
(University of the Western Cape, 2022)Human semen contains a heterogenous population of spermatozoa of which only a certain fraction is physiologically suitable for fertilization. Functional characteristics of these subpopulations and sperm separation ... -
Investigating novel aspects of the blood-brain barrier using high resolution electron microscopy
(University of the Western Cape, 2022)The blood-brain barrier (BBB) is a restrictive interface located between the blood circulation and the central nervous system (CNS), regulating the homeostatic environment of the neuronal milieu, by controlling the ... -
The association of BMI and blood pressure measurements with depressive and quality of life scores in university students
(University of the Western Cape, 2022)Depression is a very common and serious mental illness. Studies have shown that depression has a significant impact on both social and economic aspects of sufferers worldwide as well as in South Africa. Research has shown ... -
The effects of carbon-based nanoparticle surface functionalization on immune responses
(University of the Western Cape, 2022)Nano-based technologies are highly desired for the unique properties achieved through size restrictions. Nanoparticles (NPs) achieve a higher surface-to-volume ratio during synthesis. As a result there is a greater rate ... -
The paracrine effect of normoxic and hypoxic cancer secretions on blood-brain barrier endothelial cells
(University of the Western Cape, 2022)Cancer is the most common leading cause of death worldwide. Glioblastoma and breast cancer are the most aggressive solid tumour. The survival rate of these tumours depends on their ability to progress and spread. These ... -
Tyrosol production of Candida species by plant extracts used for skin treatment remedies
(University of the Western Cape, 2022)The fungal genus Candida is a collection of approximately 150 asporogenous yeast species which are able to cause life-threatening diseases when the normal host defences have been compromised. The most commonly isolated ... -
Investigating factors that influence the breeding success of the endangered African penguin (Spheniscus demersus) at a mainland and island colony in the Western Cape, South Africa
(University of Western Cape, 2022)Since the 1950s the global seabird population have declined by 70% and today some penguin species are amongst the most threatened seabirds in the world. The African penguin (Spheniscus demersus) population experienced a ...
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