Browsing by Title
Now showing items 1456-1475 of 8878
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Computational analysis of multi-omic data for the elucidation of molecular mechanisms of neuroblastoma
(University of Western Cape, 2021)Neuroblastoma is the most common extracranial solid tumor in childhood. The survival rates of patients with neuroblastoma, especially those in the high-risk category, are still low despite varied therapies. The detailed ... -
Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer
(University of the Western Cape, 2015)Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a ... -
Computational characterisation of DNA methylomes in mycobacterium tuberculosis Beijing hyper- and hypo-virulent strains
(University of the Western Cape, 2014)Mycobacterium tuberculosis, the causative agent of tuberculosis, is estimated to infect approximately one-third of the world’s population and is responsible for around 2 million deaths per year. The disease is endemic in ... -
A computational characterisation of the relationship between genome structure and disease genes
(University of the Western Cape, 2012)This is a pilot study to investigate the relationship between disease gene status and the structure of the human genome with specific reference to regions of recombination. It compares certain characteristics of a control ... -
Computational characterization of IRE-regulated genes in Glossina morsitans
(University of Western Cape, 2013)Blood feeding is a habit exhibited by many insects. Considering the devastating impact of these insects on human health, it is important to focus research on understanding the biology behind blood-feeding, disease ... -
A computational framework for transcriptome assembly and annotation in non-model organisms: the case of venturia inaequalis
(University of the Western Cape, 2014)In this dissertation three computational approaches are presented that enable optimization of reference-free transcriptome reconstruction. The first addresses the selection of bona fide reconstructed transcribed fragments ... -
Computational genomics approaches for kidney diseases in Africa
(University of the Western Cape, 2015)End stage renal disease (ESRD), a more severe form of kidney disease, is considered to be a complex trait that may involve multiple processes which work together on a background of a significant genetic susceptibility. ... -
Computational modelling of a hot-wire chemical vapour deposition reactor chamber
(University of Western Cape, 2020)In this thesis, I explore the subjects of fluid dynamics and the Hot-Wire Chemical Vapour Deposition (HWCVD) process. HWCVD, in its simplicity, is one of the more powerful and elegant deposition techniques available in ... -
Computational prediction of host-pathogen protein-protein interactions
(University of the Western Cape, 2017)Supervised machine learning approaches have been applied successfully to the prediction of protein-protein interactions (PPIs) within a single organism, i.e., intra-species predictions. However, because of the absence of ... -
Computational strategies to identify, prioritize and design potential antimalarial agents from natural products
(University of the Western Cape, 2015)Introduction: There is an exigent need to develop novel antimalarial drugs in view of the mounting disease burden and emergent resistance to the presently used drugs against the malarial parasites. A large amount of natural ... -
Computational verification of published human mutations
(University of the Western Cape, 2008)The completion of the Human Genome Project, a remarkable feat by any measure, has provided over three billion bases of reference nucleotides for comparative studies. The next, and perhaps more challenging step is to analyse ... -
Computing Mislin genera of certain groups with non-abelian torsion radicals
(University of the Western Cape, 2004)In this mini-thesis we present some generalities of non-cancellation and localization and we compute non-cancellation groups. We consider groups belonging to the class X0 of all finitely generated groups that have finite ... -
Concept Based Knowledge Discovery from Biomedical Literature
(University of the Western Cape, 2009)This thesis describes and introduces novel methods for knowledge discovery and presents a software system that is able to extract information from biomedical literature, review interesting connections between various ... -
Concept Based Knowledge Discovery From Biomedical Literature
(University of the Western Cape, 2009)Advancement in biomedical research and continuous growth of scientific literature available in electronic form, calls for innovative methods and tools for information management, knowledge discovery, and data integration. ... -
The concept of power sharing in the constitutions of Burundi and Rwanda
(University of the Western Cape, 2005)This paper aimed to analyse the impact of power sharing on democracy. The paper also compared the approach of Burundi and Rwanda in their constitutions to the concept of power sharing. -
The concept of restitution in South African economic policy documents between 1994 and 2014 : an ethical analysis
(University of the Western Cape, 2016)There is widespread concern in the democratic South African context over economic inequalities. However, given the problems of poverty, unemployment and inequality, there is a need to consider economic restitution. Restitution ... -
The concept of the Sufi Saintly Miracle: A Literary Approach
(University of Western cape, 2020)study analyses the concept of al-Karāmah al-Sūfīyah (the Sufi Saintly Miracle) in both its religious and literary dimensions. The researcher will shed more light on this genre of narrative literary phenomena by developing ... -
The concept of the Sufi Saintly Miracle: A literary approach
(University of the Western Cape, 2019)This study analyses the concept of al-Karāmah al-Sūfīyah (the Sufi Saintly Miracle) in both its religious and literary dimensions. The researcher will shed more light on this genre of narrative literary phenomena by ... -
Conceptions of conservation of energy among grade seven learners in two cape town schools
(University of Western Cape, 2021)The clamour in the country about the poor performance of learners in the area of physical science is a concern and this problem had been attributed to different facets of learning which include the amendment of curriculum ...