Browsing by Author "Syce, James"
Now showing items 1-10 of 10
-
Comparison of flavonoid profile and respiratory smooth muscle relaxant effects of Artemisia afra versus Leonotis leonurus
Tikiso, Tjokosela (University of the Western Cape, 2015)Leonotis leonurus (L. leonurus) and Artemisia afra (A. afra) are two of the most commonly used medicinal plants in South Africa traditionally advocated for use in asthma. However, proper scientific studies to validate these ... -
Comparison of the physicochemical characteristics and flavonoid release profiles of Sutherlandia frutescens phytosomes versus liposomes
Daghman, Mohamed Ibrahim (University of the Western Cape, 2016)Sutherlandia frutescens is a traditional plant medicine widely used in South Africa. Traditionally, the leaves of S. frutescens are mainly used as a tea, but these traditional dosage forms have several disadvantages, ... -
Computational strategies to identify, prioritize and design potential antimalarial agents from natural products
Egieyeh, Samuel Ayodele (University of the Western Cape, 2015)Introduction: There is an exigent need to develop novel antimalarial drugs in view of the mounting disease burden and emergent resistance to the presently used drugs against the malarial parasites. A large amount of natural ... -
Content levels, in vitro dissolution and predicted bioavailability of flavonoids from Sutherlandia frutescens leaf powder and aqueous extracts
Mbamalu, Oluchi Nneka (University of the Western Cape, 2015)Various formulations of the popular South African medicinal plant, Sutherlandia frutescens,are commercially available, with no documented specifications for quality assessment. With plans already underway for a clinical ... -
The effect of Cyclopia maculata on AMPK expression in Wistar rats
Jacobs, Carvern Denver (University of the Western Cape, 2012)Being overweight or obese are major factors contributing to the increased morbidity and mortality due to non-communicable diseases such as type 2 diabetes, cardiovascular disease and cancer. The treatment of obesity with ... -
The effects of maternal diets, varying in fat content, on proximal hepatic and skeletal muscle insulin signalling in neonatal wistar rat offspring
Ndlovu, Zibele (University of the Western Cape, 2013)The incidence of type 2 diabetes (T2D) is persistently increasing globally. T2D is associated with pancreatic β cell dysfunction and insulin resistance in peripheral tissues such as the liver and skeletal muscle. Skeletal ... -
The evaluation of microwave drying on the polymorphic characteristics of carbamazepine granules prepared by the wet granulation process.
Smith, Marco (Univeraity of the Western Cape, 2006)The drying conditions of granules for tabletting prepared by the wet granulation process traditionally involve conduction, convection and radiation heat transfer. Despite various technological advances utilizing combinations ... -
An evaluation of the Bronchodilator properties of Mentha longifolia and Artemisia afra, traditional medicinal plants used in the Western Cape.
Harris, Lynne (University of the Western Cape, 2002)The overall objective of this study was to investigate the claims that Mentha longifulia (ML) and Artemisia afra (AA) have anti-asthmatic properties. To realize this objective we were to determine the effects that the ... -
The development and preparation of a quality control dossier for registration of Artemisia Afra capsules for the treatment of chronic Asthma by the South African health products regulatory authority
Sekhonyana-Khetsekile, Mabolaeng (University of the Western Cape, 2018)The aim of this study was to determine quality control specifications needed for a dossier and an investigator's brochure of A. afra capsules, which can be used to motivate the registration and clinical testing of A. afra ... -
Use of antioxidant activity and flavonoid levels to assess the quality of commercially available solid dose Sutherlandia frutescens products
Hess, Meggan Sade (University of the Western Cape, 2010)The overall aims of this project were to assess the pharmaceutical quality and consistency of commercially available solid dose Sutherlandia frutescens containing products (viz. tablets & capsules) by exploring the use of ...