Browsing by Author "Trindade, Marla"
Now showing items 1-20 of 21
-
Bioactivity and genome guided isolation of a novel antimicrobial protein from Thalassomonas viridans
Adams, Shanice Raquel (University of the Western Cape, 2019)The continued emergence of bacterial resistance to the antibiotics currently employed to treat several diseases has added to the urgency to discover and develop novel antibiotics. It is well established that natural products ... -
Biochemical characterisation of an alpha-amylase with pullulan hydrolase type III characteristics derived from a hot spring metagenomics library
Boersma, Bianca (University of the Western Cape, 2024)The field of metagenomics has provided biotechnological researchers with new enzymes and insight into previously unknown enzyme families with potential for novel modes of action and being able to function under extreme ... -
Biochemical characterization of β-xylosidase and β-glucosidase isolated from a thermophilic horse manure metagenomic library
Ndata, Kanyisa (University of the Western Cape, 2020)The complete degradation of recalcitrant lignocellulose biomass into value-added products requires the efficient and synergistic action of lignocellulose degrading enzymes. This has resulted in a need for the discovery of ... -
Biodiscovery of Novel Bioactivities from the South African Marine Environment
Hoosen, Reyghana (University of the Western Cape, 2016)There is currently a global health crisis taking place, which is the increasing occurrence of drug-resistant pathogens within clinical microorganisms. Drugresistant pathogens are increasingly becoming more difficult to ... -
Biological approach to improving the evaporation rates of mine wastewater desalination brine treated in evaporation ponds
Moyo, Anesu Conrad (University of the Western Cape, 2021)The disposal of brine effluent from inland wastewater desalination plants is a growing global problem with adverse economic and environmental implications because of the substantial cost associated with its disposal and ... -
Biosurfactant screening through metagenomic and culture-based approaches
Sithole, Nombuso Slindile (University of the Western Cape, 2022)The biosurfactant market is still predominantly represented by the three main products: surfactin, sophorolipids, and rhamnolipids, mainly as a result of the high cost and low yield associated with biosurfactant production. ... -
Comparison of plasmids from clinical Lactobacillus strains
Harris, Lyle Keenan (University of the Western Cape, 2018)The vaginal mucosa is dominated by Gram positive, rod shaped lactobacilli which serve as a natural barrier against infection. In both healthy and BV infected women Lactobacillus crispatus and Lactobacillus jensennii has ... -
Comparison of plasmids from clinical Lactobacillus strains
Lyle Keenan , Harris (University of the Western Cape, 2018)The vaginal mucosa is dominated by Gram positive, rod shaped lactobacilli which serve as a natural barrier against infection. In both healthy and BV infected women Lactobacillus crispatus and Lactobacillus jensennii has ... -
Development of a high throughput cell-free metagenomic screening platform
Nevondo, Walter (University of the Western Cape, 2016)The estimated 5 × 10³⁰ prokaryotic cells inhabiting our planet sequester some 350–550 Petagrams (1 Pg = 1015 g) of carbon, 85–130 Pg of nitrogen, and 9–14 Pg of phosphorous, making them the largest reservoir of those ... -
Development of a novel high throughput method for identifying phage-host pairs in an extreme environment
Olonade, Israel Temiloluwa (University of the Western Cape, 2017)There are approximately 10³¹ bacteriophages in the biosphere, outnumbering bacteria 10:1, hence, the dynamic and specific nature of phage-host interactions exerts significant influence on microbial communities. Bacteriophages ... -
Discovery of antibacterial lead compounds from marine organisms
Afolayan, Omolola (University of the Western Cape, 2020)Marine organisms including algae and bacteria are known to produce chemically diverse secondary metabolites for survival purposes in the marine environment. Scientists have identified some of these natural products as ... -
Discovery of biomolecules from South African marine sponge symbionts through Metagenomic studies
Mapatha, Matlakala Reginah (University of the Western Cape, 2018)Marine sponges are known to harbour diverse microorganisms which have been proposed to be involved in the synthesis of most of the natural compounds derived from sponges. However, only about 1% of these microorganisms can ... -
Engineering Parageobacillus thermoglucosidans as a robust platform for bioethanol production
van Zyl, Leonardo Joaquim (University of the Western Cape, 2018)Parageobacillus thermoglucosidans is a promising “platform” organism to use in the production ofa range of useful metabolites with demonstrated ability to produce ethanol, isobutanol and polylactic acid for bio-degradable ... -
Improving Evaporation Rate of Mine Wastewater
Khumalo, Londiwe Thandeka Precious (University of the Western Cape, 2018)The treatment of mine water at the eMalahleni Water Reclamation Plant (EWRP) results in the production of large volumes of brine. Different brine management methods have been applied to dispose the brine but the evaporation ... -
Investigating the antimicrobial potential of Thalassomonas actiniarum
Pheiffer, Fazlin (University of the Western Cape, 2020)bioassay guided isolation approach was then used to isolate the high molecular weight antibacterial compound (50kDa-100kDa) from T. actiniarum fermentations. With common protein isolation, purification and detection methods ... -
Investigating the antimicrobial potential of Thalassomonas actiniarum
Pheiffer, Fazlin (University of Western Cape, 2020)The World Health Organisation predicts that by the year 2050, 10 million people could die annually as a result of infections caused by multidrug resistant bacteria. Individuals with compromised immune systems, caused by ... -
The isolation and characterisation of a novel siderophore from the marine bacterium Thalassomonas viridans
Cooper, Amy (University of the Western Cape, 2022)Natural products (NPs) produced by bacteria, fungi, plants, and marine animals include a large group of diverse chemical entities that display a broad range of biological activities. NPs are widely used for various ... -
Isolation and preliminary characterization of bacteriophages of thermophilic Bacillus and Geobacillus species
Emedi, Babele Timothee (University of the Western Cape, 2015)Thermophilic bacteriophages provide simple model systems for understanding biochemical and biological adaptation mechanisms at elevated temperatures. The essential objectives of this study were to characterise the ... -
Marine bacteria as a potential source for novel antimicrobial compounds
Segopa, Ellen Kelebogile (University of the Western Cape, 2020)The high rate of rediscovery of known compounds has led to a decline in the discovery of novel natural products. The high biodiversity of organisms growing in extreme conditions such as oceans has led to the increased ... -
Screening bacterial symbionts of marine invertebrates for ribosomally synthesized natural products
Hanekom, Thea (University of the Western Cape, 2016)Pharmaceutical research and development strategies rely on the constant discovery of novel natural products as potential drugs. Recent studies have shown that the microorganisms associated with sponges are the true producers ...