Search
Now showing items 1-7 of 7
Development of a simple artificial intelligence method to accurately subtype breast cancers based on gene expression barcodes
(University of the Western Cape, 2018)
INTRODUCTION:
Breast cancer is a highly heterogeneous disease. The complexity of achieving an accurate diagnosis and an effective treatment regimen lies within this heterogeneity. Subtypes of the disease are not simply ...
An evaluation of galaxy and ruffus-scripting workflows system for DNA-seq analysis
(University of the Western Cape, 2018)
Functional genomics determines the biological functions of genes on a global scale by
using large volumes of data obtained through techniques including next-generation
sequencing (NGS). The application of NGS in biomedical ...
Identification and ranking of pervasive secondary structures in positive sense single-stranded ribonucleic acid viral genomes
(University of the Western Cape, 2018)
The plasticity of single-stranded viral genomes permits the formation of secondary structures
through complementary base-pairing of their component nucleotides. Such structures have
been shown to regulate a number of ...
Data Science techniques for predicting plant genes involved in secondary metabolites production
(University of the Western Cape, 2018)
Plant genome analysis is currently experiencing a boost due to reduced costs associated with the
development of next generation sequencing technologies. Knowledge on genetic background can be
applied to guide targeted ...
Exploring the role of the “glycan-shield” of human immunodeficiency virus in susceptibility to, and escape from, broadly neutralising antibodies
(University of the Western Cape, 2018)
The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune
response and a critical vaccine candidate. However, Env is densely glycosylated and
thereby substantially protected from neutralisation. ...
Development of a data processing toolkit for the analysis of next-generation sequencing data generated using the primer ID approach
(University of the Western Cape, 2018)
Sequencing an HIV quasispecies with next generation sequencing technologies yields a dataset with
significant amplification bias and errors resulting from both the PCR and sequencing steps. Both the
amplification bias ...
Development of Open source Laboratory Information Management System (LIMS) For Human Biobanking
(University of the Western Cape, 2018)
Biobanks are collections of biological samples and associated data for future use. The day to
day activities in a biobank laboratory is underpinned by a laboratory information management
system (LIMS). For example, the ...