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Now showing items 41-50 of 106
Determination of pyrazinamide plasma concentrations using lc-ms and pharmacokinetics of pyrazinamide in patients with multidrug-resistant tuberculosis and in patients co-infected with multidrug-resistant tuberculosis and HIV
(2013)
Tuberculosis and HIV are arguably South Africa’s largest and most important health issues. With drug-resistant strains of tuberculosis on the increase and little research on new drugs, there is an urgent need for research ...
Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive wistar rats
(University of the Western Cape, 2011)
Tulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family, Alliaceae, most commonly associated with onions and garlic. In South Africa (SA), this herb has been traditionally used in the ...
Pharmaceutical evaluation of phela capsules Used as traditional medicine
(University of the Western Cape, 2010)
In conclusion, the results obtained firstly indicated that the BP, EMEA and WHO were in fairly good agreement on the criteria and specifications that can be used to assesses the pharmaceutical quality of a traditional plant ...
Evaluation of antihistamines for in vitro antimalarial activity against Plasmodium falciparum
(2010)
The declining efficacy of antimalarial drugs against resistant Plasmodium falciparum strains in several endemic regions has amplified the world’s burden of neglected diseases. This has highlighted the need for alternate ...
Pharmacological evaluation of antidiarrhoeal and antidiabetic activities of Syzygium Cordatum Hochst. ex C. Krauss
(University of the Western Cape, 2011)
Syzygium cordatum is a medicinal plant indigenous to South Africa and Mozambique, commonly used to treat stomach aches, diabetes, respiratory problems and tuberculosis. In spite of the folklore use, adequate scientific ...
Design, Synthesis and Evaluation of Indole Derivatives as Multifunctional Agents against Alzheimer's disease.
(University of the Western Cape, 2017)
Alzheimer's disease (AD) is an age related neurodegenerative disorder characterised by
progressive memory loss and cognitive impairment. It is one of several
neurodegenerative disorders occurring as a result of a process ...
Population pharmacokinetics of terizidone and cycloserine in patients with drugresistant tuberculosis
(University of the Western Cape, 2019)
Introduction: Drug-resistant tuberculosis remains a major world health problem and
one of the leading cause of death worldwide. Despite adequate adherence to antituberculosis
drugs by patients, the emergence of drug-resistance ...
Polycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugs
(University of the Western Cape, 2017)
Recent scientific findings have highlighted the beneficial roles of polycyclic cage compounds in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Further interest into the chemistry of these compounds ...
The development and preparation of a quality control dossier for registration of Artemisia Afra capsules for the treatment of chronic Asthma by the South African health products regulatory authority
(University of the Western Cape, 2018)
The aim of this study was to determine quality control specifications needed for a dossier and an investigator's brochure of A. afra capsules, which can be used to motivate the registration and clinical testing of A. afra ...
Analysis on access to antiretroviral therapy for patients with different income and educational level, and the effect of treatment on quality of life after two to three months of therapy
(University of the Western cape, 2017)
Access to antiretroviral therapy (ART) for HIV positive patients has brought
hope and a chance to a healthier longer life with improved quality of life (QoL). In this study we
explored the difference in health related ...