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Now showing items 51-60 of 68
Antiasthmatic properties of Lippia javanica and Myrothamnus flabellifolius using an in vitro model
(University of the Western Cape, 2022)
Asthma is a reversible, chronic inflammatory disease
that causes obstruction to the airways that causes an increase in airway hyperresponsiveness
that leads to recurrent episodes of chest tightness and coughing.
Lippia ...
Homology modelling and characterization of three-dimensional (3d) protein structures of selected variants of cyp3a4
(University of the Western Cape, 2022)
The efficacy and toxicity of several drugs and prodrugs are influenced by the interindividual
genetic variations in drug-metabolising enzymes. Cytochrome P450
enzymes constitute the major metabolising enzymes in humans. ...
Factors affecting the pharmacokinetics of vancomycin in children admitted to the intensive care unit (icu) of the Red Cross War Memorial Children's Hospital (RCWMCH).
(University of the Western Cape, 2023)
Vancomycin is a glycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminal end of cell wall precursor units preventing the elongation and cross-linkage of the ...
Investigation of suitable microencapsulation techniques in the preformulation of selected antiretroviral drugs
(University of the Western Cape, 2022)
Background: The use of antiretroviral drugs (ARVDs) in the treatment of HIV/AIDS have been promising and effective especially amongst adults as it suppresses the viral load, thereby improving the life expectancy of HIV ...
Investigation of common deficiencies observed in scientific assessments and the implementation of a new robust review pathway, the risk-based assessment approach, by the South African Health Regulatory Authority, SAHPRA
(University of the Western Cape, 2022)
The main objective of this study is to improve patient access to medicines. The research is two-fold, the
first component promotes transparency between the South African Health Products Regulatory
Authority (SAHPRA), ...
Synthesis and characterisation of biomimetic immunostimulatory lipid-polymer hybrid nanoparticles
(University of the Western Cape, 2022)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis),
remains a fatal infectious disease and one of the top ten leading causes of mortality,
particularly in developing countries. Current drug therapy ...
A comparison between estimated renal function from point-of care derived cystatin c measurements and serum creatinine derived measurements
(University of the Western Cape, 2022)
Serum Creatinine (SCr) is the most commonly used and cost effective
biomarker used to quantify estimated glomerular filtration rate. However, creatinine is
affected by anthropometric parameters such as muscle mass, age ...
Evaluation of selected polycyclic compounds as resistance modulators in Mycobacterium tuberculosis
(University of the Western Cape, 2022)
Progressive development of resistance to various chemotherapeutic agents used in the management
of infectious diseases presents a serious problem in global public health. Increasing levels of
antimicrobial resistance in ...
Assessing the influence of electronic media on student perceptions towards antibiotic resistance
(University of the Western Cape, 2022)
Antimicrobial resistance (AMR) and the reduced number of new antibiotic
discoveries impose a major threat to the quality of human life and effective
treatment options. Antibiotic resistant infections require prolonged ...
The implementation of the African union model law on medical products regulation and the establishment of the African medicines agency
(University of the Western Cape, 2022)
Within Africa, there is insufficient access to quality, safe, efficacious and
affordable medical products which can partly be attributed to lack of robust
regulatory systems, a lack of competent regulatory professionals ...