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Determination of kanamycin plasma concentrations using LC/MS and pharmacokinetics of kanamycin in patients with multidrug-resistant tuberculosis and in patients with multidrug-resistant tuberculosis co-infected with HIV
(University of the Western Cape, 2012)
The aim of the study was to determine firstly, kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC/MS); secondly, to investigate the PK parameters of kanamycin in patients infected ...
Determination of pyrazinamide plasma concentrations using lc-ms and pharmacokinetics of pyrazinamide in patients with multidrug-resistant tuberculosis and in patients co-infected with multidrug-resistant tuberculosis and HIV
(2013)
Tuberculosis and HIV are arguably South Africa’s largest and most important health issues. With drug-resistant strains of tuberculosis on the increase and little research on new drugs, there is an urgent need for research ...
Ethionamide pharmacokinetics in multidrugresistant tuberculosis patients with and without HIVinfection
(University of the Western Cape, 2017)
Many studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs
in tuberculosis patients. However, currently in South Africa, no studies have been
done on ethionamide (ETH) PK in adult MDR-TB patients ...
Formulation of a nevirapine co-crystal as a liquid dosage form
(University of the Western Cape, 2016)
Co-crystals are a solid phase phenomena that could enhance the physicochemical properties of an active pharmaceutical ingredient. A co-crystal has never been incorporated into a liquid dosage form with the assurance of ...