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Now showing items 11-20 of 20
A dual analysis of the South African Griqua population using ancestry informative mitochondrial DNA and discriminatory short tandem repeats on the Y chromosome
(University of the Western Cape, 2015)
The primary objective of this Masters project was to investigate the maternal ancient substructure of the Griqua population in South Africa. Genetic ancestry was determined by investigating ancestry informative single ...
In vitro investigation of the ubiquitination and degradation of p53 by Murine Double Minute 2 (MDM2) and Retinoblastoma Binding Protein 6 (RBBP6)
(University of the Western Cape, 2015)
P53 is one of the most important tumour suppressor proteins in the body which protects the cell against the tumourigenic effects of DNA damage by initiating processes such as apoptosis, senescence and cell cycle arrest. ...
Isolation and preliminary characterization of bacteriophages of thermophilic Bacillus and Geobacillus species
(University of the Western Cape, 2015)
Thermophilic bacteriophages provide simple model systems for understanding
biochemical and biological adaptation mechanisms at elevated temperatures. The
essential objectives of this study were to characterise the ...
Identification and validation of micrornas for diagnosing type 2 diabetes : an in silico and molecular approach
(University of the Western Cape, 2015)
Type 2 diabetes mellitus (T2DM), a metabolic disease characterized by chronic hyperglycemia, is the most prevalent form of diabetes globally, affecting approximately 95 % of the total number of people with diabetes i.e. ...
Zirconium-induced physiological and biochemical responses in two genotypes of Brassica napus L.
(University of the Western Cape, 2015)
South Africa is one of two countries responsible for the production of approximately
80% of the world’s Zr. The increase in mining activity has detrimental effects on the
environment, especially crop plants, as more ...
Development of a plum chromosome doubling method and proteomics and biochemical characterization
(University of the Western Cape, 2015)
Chromosome doubling has become an important tool in breeding programmes as it offers the ability of introducing novel traits into existing plants. Doubled haploid plants are highly valued by both consumers and breeders as ...
A biochemical and proteomic analysis of sugargraze sorghum under hyperosmotic stress
(University of the Western Cape, 2015)
Sugargraze is a moderately drought tolerant sweet sorghum hybrid which is ideal for grazing, winter stand over and pit silage. A major advantage that Sugargraze has over other forages is its very high sugar content which ...
The degradation of the endocrine disrupting chemical, bisphenol-A : a comparative study between fungal and bacterial laccases
(University of the Western Cape, 2015)
The degradation of endocrine disrupting chemicals (EDCs) is a topic of high importance and one that research efforts are continually being focused on. These harmful chemicals are known to cause adverse health effects in ...
Synthesis of silver nanoparticles and investigating their antimicrobial effects
(University of the Western Cape, 2015)
Water is essential for life, yet access to safe drinking water is still a major concern worldwide due to waterborne diseases. The current study proposes silver nanoparticles (AgNPs) as an antibacterial agent. Silver ...
Characterization of the role of single domain soybean cystatins in regulating drought responses in soybean
(University of the Western Cape, 2015)
This study investigated the effects that drought stress imposed on the growth and development of soybean plants. Soybeans were initially observed at the whole-plant level in order to identify the physical changes that had ...