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Now showing items 131-140 of 169
Single nucleotide polymorphism association studies of ABCA13 and ABHD11 genes and the bioinformatics analysis of the autism candidate genes localized on chromosome 7
(University of the Western Cape, 2016)
Autism, Aspergers Syndrome and Pervasive Developmental Delay-Not Otherwise Specified (PDD-NOS), among others, fall under an umbrella of disorders known as Autism Spectrum Disorder. Twin studies show that autism is a highly ...
Physiological and molecular characterization of wheat cultivars to Fusarium oxysporum infection
(University of the Western Cape, 2019)
Biotic stress is one of the main causes for agricultural loss of economically important cereal crops. The increasing prevalence of biotic stress inflicted by fungal species such as Fusarium has significantly reduced yields ...
Comparison of plasmids from clinical Lactobacillus strains
(University of the Western Cape, 2018)
The vaginal mucosa is dominated by Gram positive, rod shaped lactobacilli which serve as a
natural barrier against infection. In both healthy and BV infected women Lactobacillus
crispatus and Lactobacillus jensennii has ...
Deciphering a potential cytoprotective role of novel heat shock responsive proteins using a proteomic approach
(University of the Western Cape, 2011)
Myocardial infarction, commonly known as a heart attack, is a condition where the blood supply to the heart tissue is cut off, starving the tissue from oxygen and nutrient supply, with consequent lethal damage to the heart ...
Investigation of the link between drought-induced changes in the expression of a novel sterol biosynthesis gene and drought tolerance in soybean
(University of the Western Cape, 2017)
Glycine max (soybean) is an important crop species globally as it is used as a protein-rich food
and feed crop and as a source of oils used in the food and biofuel industry. However, the
growth and yield of soybean is ...
Discovery of biomolecules from South African marine sponge symbionts through Metagenomic studies
(University of the Western Cape, 2018)
Marine sponges are known to harbour diverse microorganisms which have been proposed to
be involved in the synthesis of most of the natural compounds derived from sponges.
However, only about 1% of these microorganisms can ...
Recombinant expression of cytochrome P450-2D6 and its application in tamoxifen metabolism
(University of the Western Cape, 2018)
Breast cancer is regarded as the most common form of cancer in women and it comprises of
approximately 23 % of female cancers, while affecting women at any age range. For
oestrogen receptor positive patients, tamoxifen is ...
Characterization of the role of a cycloartenol synthase gene (ZMCAS494) in Zea mays responses to drought stress
(University of the Western Cape, 2016)
Plant Sterols are an important part of the membrane and their role is to control cell membrane
fluidity and permeability. Several studies have indicated that plants that are mutant for genes
that play a role in the sterol ...
Structural Analysis of Induced Mutagenesis Protein B from Mycobacterium tuberculosis Jeremy
(University of the Western Cape, 2016)
Knowing the three-dimensional structure of a protein may be useful in understanding its function.
In this study, induced mutagenesis protein B (ImuB) from Mycobacterium tuberculosis was
analyzed using molecular biology and ...
Identification of novel miRNAs as diagnostic molecules for detection of breast cancer using in silico approaches
(University of the Western cape, 2017)
Breast cancer (BC) is the most common cancer in women worldwide, and is the
second most common cancer in the world, responsible for more than 500 000 deaths
annually. Estimates are that 1 in 8 women will develop BC in their ...