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Comparative analysis of molecular and physiological responses of two canola genotypes to drought stress
(University of the Western Cape, 2016)
Food security has always been one of the priority concerns in Africa, and it is mostly
threatened by drought stress due to climate change. Drought-induced stress is one of the serious limiting factors of plant production, ...
Screening bacterial symbionts of marine invertebrates for ribosomally synthesized natural products
(University of the Western Cape, 2016)
Pharmaceutical research and development strategies rely on the constant discovery of novel natural products as potential drugs. Recent studies have shown that the
microorganisms associated with sponges are the true producers ...
Development of genotyping systems for pharmacogenomics profiling
(University of the Western Cape, 2016)
Genetic variability in genes encoding drug metabolizing enzymes, transporters and targets are known to be the main factors of inter-individual differences in therapeutic outcome. Genetic factors are estimated to be responsible ...
Bioprospecting for bioactive polysaccharides from marine algae endemic to South Africa
(University of the Western Cape, 2016)
Fucoidan is a marine-derived sulphated polysaccharide with bioactive properties ideal for the food, chemical and pharmaceutical industries. The polysaccharide consists largely of L-fucose, has a highly heterogeneous structure ...
Proteome signature of breast cancer cells treated with fucoidan
(University of the Western Cape, 2016)
Breast cancer is responsible for a large portion of cancer-related deaths. Worldwide, incidence is increasing. Routinely-used treatments for breast cancer are invasive and are associated with a range of side-effects which ...
Modulation of brassica rapa L. antioxidant activities by exogenous methylglyoxal under zirconium stress
(University of the Western Cape, 2016)
With a decrease in water availability and arable land, and the ever-increasing reports of toxic chemical pollutants, it is crucial to elucidate plants’ mechanisms of adaptability to these abiotic stressors. South Africa ...
Characterisation of N-terminal fragments of Retinoblastoma Binding Protein 6 for structural analysis
(University of the Western Cape, 2016)
Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa RING finger-containing protein that plays a role in 3'-end poly-adenylation of mRNA transcripts as well as acting as an E3 ubiquitin ligase against a number of proteins ...
A comparative proteomic analysis of two contrasting Salvia hispanica L. genotypes under salinity stress
(University of the Western cape, 2016)
Salvia hispanica L. is an annual pseudocereal food crop, locally known as chia that has the ability to grow in water stress environments. The importance of chia dates back to the pre-columbian era where it was consumed as ...
Functional analysis of miRNA regulated genes in prostate cancer as potential diagnostic molecules
(University of the Western Cape, 2016)
Prostate Cancer is the leading cause of cancer-related death in males in the Western world. It is a common biological disease originating from the reproductive system of the male namely, the prostate gland, usually in older ...
The assessment of the bactericidal effect of green synthesized silver nanoparticles against a panel of infectious microorganisms
(University of the Western Cape, 2016)
The emergence of multiple drug resistant microorganisms poses a major threat to human life. These microorganisms have made the currently used antibiotics ineffective and therefore continue to thrive. Therefore, there is a ...