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Now showing items 11-20 of 50
The structure, function and engineering of a thermostable nitrile hydratase
(University of the Western Cape, 2008)
Nitrile hydratases (NHases) are enzymes that catalyse the conversion of organocyanides to amides via a non-hydrolytic hydration reaction. They are industrially relevant enzymes, currently used in the manufacture of ...
Genetic analysis of resistance to apple scab (Venturia inaequalis) in apple (Malus x domestica Borkh)
(University of the Western Cape, 2007)
Amongst the many problems facing the apple industry, apple scab is one of the most challenging experienced by producers. This disease is caused by Venturia inaequalis, which causes lesions to develop on both the fruit and ...
Gene Discovery in Antarctic Dry Valley Soils
(University of the Western Cape, 2008)
The metagenomic approach to gene discovery circumvents conventional gene and gene product acquisition by exploiting the uncultured majority of microorganisms in the environment. It was demonstrated in this study that ...
Systematic approach to protein crystallization: emphasis on Vaccinia virus complement control protein (VCP)
(University of the Western Cape, 2006)
This work examined the systematic approach to protein crystallization, exploring some of the techniques that have been developed to enhance the success rate of crystallization. The work was centered on two proteins; namely ...
Screening of natural products and alkylating agents for antineoplastic activity
(University of the Western Cape, 2007)
Background and objectives: Apoptosis is a process in which a cell programmes its own death. It is a highly organized physiological mechanism in which injured or damaged cells are destroyed. Apart from physiological stimuli ...
The Internal Validation and Casework Application of MiniSTR Systems
(University of the Western Cape, 2008)
The objective of the study was to conduct an internal validation on miniSTR systems and apply it to cases received from the South African Missing Persons Task Team (SAMPTT). This was prompted by the fact that miniSTR systems ...
Spartial distribution of cyanobacterial phylotypes in Antarctic Dry Valley soil biotopes
(University of the Western Cape, 2007)
Recent advances in moleculr methods have enabled the analysis of cyanobacterial diversity using PCR- based approaches. Snap-shot techniques such as 16S rDNA library construction and DGGE have allowed for increased access ...
The identification of candidate genes using cDNA microarray and the analysis of two SNPs of the reelin gene in a South African austistic population
(University of the Western Cape, 2009)
Autism is a pervasive developmental disorder (PDD) that's incidence is approximately 1 in 158. It is four times more prevalent in males than females and is believed to be caused by both genetic and environmental factors. ...
The evaluation of Y-STR loci for use in forensics
(University of the Western Cape, 2005)
The aim of this study was to investigate the forensic usefulness of various Y-chromosome short tandem repeat loci among South African sub-populations. Three different sets of Y-chromosome short tandem repeat loci were ...
Characterisation of eight non-codis Ministrs in four South African populations to aid the analysis of degraded DNA
(University of the Western Cape, 2009)
In many forensic cases, such as mass disasters reconstruction cases, the recovered DNA is highly degraded. In such incidences, typing of STR loci has become one of the most powerful tools for retrieving information from ...