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A mathematical model for studying the impact of climate variability on malaria epidemics in South Africa
(University of the Western Cape, 2017)
Malaria is most prevalent in tropical climates, where there are sufficient rainfall
for mosquitoes to breed and conducive temperatures for both the mosquito and
protozoa to live. A slight change in temperature can ...
Identification and characterization of microRNAs and their putative target genes in Anopheles funestus s.s
(2013)
The discovery of microRNAs (miRNAs) is one of the most exciting scientific
breakthroughs in the last decade. miRNAs are short RNA molecules that do not encode proteins but instead, regulate gene expression. Over the past ...
Statistical modelling of clustered and incomplete data with applications in population health studies in developing countries
(University of Western Cape, 2014)
The United Nations (UN) Millennium Development Goals (MDGs) drafted eight goals to
be achieved by the year 2015, namely: eradicating extreme poverty and hunger, achieving universal primary education, promoting gender ...
Mathematical modeling of the transmission dynamics of malaria in South Sudan
(University of the Western Cape, 2019)
Malaria is a common infection in tropical areas, transmitted between humans
through female anopheles mosquito bites as it seeks blood meal to carry out
egg production. The infection forms a direct threat to the lives of ...
Analysis and implementation of robust numerical methods to solve mathematical models of HIV and Malaria co-infection
(University of the Western Cape, 2011)
There is a growing interest in the dynamics of the co-infection of these two diseases. In this thesis, firstly we focus on studying the effect of a distributed delay representing the incubation period for the malaria ...
Novel aminoquinoline-polycyclic hybrid molecules as potential antimalarial agents
(University of the Western Cape, 2014)
Plasmodium falciparum malaria continues to be a worldwide health problem, especially in developing countries in Africa and is responsible for over a million fatalities per annum. Chloroquine (CQ) is low-cost, safe and was ...
Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
(University of the Western Cape, 2020)
Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are ...
An investigation into combined amorphous form of sufadoxine, pyrimethamine and azithromycin
(University of Western Cape, 2021)
Malaria remains one of the top mortality causes in the sub-Saharan African region, especially
among pregnant women and infants. Despite several measures being implemented within the
affected areas such as the use of ...
Structure-Based Virtual Screening of Selected Malaria Box Compounds Against a Multi-Staged Protein (Falstatin) in Plasmodium falciparum
(University of the Western Cape, 2021)
Malaria disease poses substantial health risks to many nations, especially in Africa, where it primarily affects pregnant women, children, and immunocompromised patients. However, current antimalarial drugs have limitations ...