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Computational strategies to identify, prioritize and design potential antimalarial agents from natural products
(University of the Western Cape, 2015)
Introduction: There is an exigent need to develop novel antimalarial drugs in view of the mounting disease burden and emergent resistance to the presently used drugs against the malarial parasites. A large amount of natural ...
The isolation and characterisation of novel natural products from marine bacterial symbionts
(University of the Western Cape, 2015)
Drug-resistant infections are a global health crisis and drastically hinder the treatment options to effectively combat disease. Today, natural products remain an important source of novel drug candidates. Micro-organisms, ...
Biochemical investigation of anti-cancer activity of Tulbaghia violacea
(UWC, 2012)
Natural products have been a source of many pharmaceutical drugs and a number of drugs that are currently used in the treatment of cancer are derivatives of compounds originally isolated from natural products. There is ...
Screening of natural products and alkylating agents for antineoplastic activity
(2007)
Apoptosis is a process in which a cell programmes its own death. It is a highly organized physiological mechanism in which injured or damaged cells are destroyed. Apart from physiological stimuli however, exogenous factors ...
Screening of natural products and alkylating agents for antineoplastic activity
(University of the Western Cape, 2007)
Background and objectives: Apoptosis is a process in which a cell programmes its own death. It is a highly organized physiological mechanism in which injured or damaged cells are destroyed. Apart from physiological stimuli ...
Screening extracts of indigenous South African plants for the presence of anti-cancer compounds
(University of the Western Cape, 2006)
Early man dabbled with the use of plant extracts to cure ailments. This practice has been passed down from generation to generation and today more than 50% of the world'sdrugs are natural products or derivatives thereof. ...
Cheminformatic Approaches to Hit-Prioritization and Target Prediction of Potential Anti-MRSA Natural Products
(University of the Western Cape, 2020)
The growing resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) to currently prescribed drugs has resulted in the failure of prevention and treatment of different infections caused by the superbug. Therefore, ...
Discovery of anti-mycobacterial natural products from South African marine algae
(University of the Western Cape, 2019)
Tuberculosis is a communicable disease which affects millions of people around the world.
Although the case reports are declining, the eradication rate of this disease is far too slow.
Natural products have played a key ...
Cheminformatic approaches to hit-prioritization and target prediction of potential anti-mrsa natural products
(University of Western Cape, 2020)
The growing resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) to currently prescribed drugs has resulted in the failure of prevention and treatment of different infections caused by the superbug. Therefore, ...
Isolation and characterization of natural products from selected Rhus species
(University of Western Cape, 2020)
Searsia is the more recent name for the genus (Rhus) that contains over 250 individual species of flowering plants in the family Anacardiaceae. Research conducted on Searsia extracts to date indicates a promising potential ...