A comparison between estimated renal function from point-of care derived cystatin c measurements and serum creatinine derived measurements

Abstract

Serum Creatinine (SCr) is the most commonly used and cost effective biomarker used to quantify estimated glomerular filtration rate. However, creatinine is affected by anthropometric parameters such as muscle mass, age and gender. Cystatin-C (CysC) is a low molecular weight protein which is freely filtered through the glomerulus. It has been said to be as accurate as plasma creatinine and is independent of limitations derived from anthropometric parameters. CysC can also be determined through point of care devices which do not require the phlebotomy or experienced laboratory personnel for its use. There have also been correlations noted in CysC serum concentrations and cardiovascular risk assessment.