Browsing Philosophiae Doctor - PhD (Biotechnology) by Title
Now showing items 23-42 of 98
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Development of a receptor targeted nanotherapy using a proapoptotic peptide
(University of the Western Cape, 2015)The prevalence of obesity amongst South Africans is alarming, with more than 29% of men and 56% of women considered to be obese. Angiogenesis, a process for development of new blood vessels play a major role in growth and ... -
The development of nanotechnology-based detection systems for the diagnosis of breast cancer
(University of the Western Cape, 2015)Breast cancer is one of the major causes of death in South Africa. About 1 in 29 South African women are at risk of developing this type of cancer in their lifetime. The global incidence of breast cancer also increases ... -
Development of nanotechnology-based drug delivery and imaging system to the white adipose tissue vasculature using Wistar Rat Model
(University of the Western Cape, 2013)Obesity is a complex metabolic disease of excessive fat accumulation. It is a worldwide epidemic affecting billions of people and its pharmacological management is hampered by drug toxicity and undesirable side effects. ... -
Diversity of Frankia associated with Morella species of the Cape floristic region of Southern Africa
(University of the Western Cape, 2016)Frankia is one of two partners in the globally distributed N2-fixing actinorhizal symbiosis between this filamentous soil-dwelling actinomycete and almost 300 species of host plants from eight diverse angiosperm families. ... -
Engineering Parageobacillus thermoglucosidans as a robust platform for bioethanol production
(University of the Western Cape, 2018)Parageobacillus thermoglucosidans is a promising “platform” organism to use in the production ofa range of useful metabolites with demonstrated ability to produce ethanol, isobutanol and polylactic acid for bio-degradable ... -
Evaluation of the capacity of hydrogen sulfide to reduce infection of maize
(University of the Western Cape, 2020)Maize (Zea mays L.) is grown globally as an important grain crop in South Africa, United States, China and Brazil and plays a major role in the worldwide economy. In South Africa, the grain is utilised for food consumption, ... -
Expression of recombinant S-locus F-box-S2 protein and computational modeling of protein interaction at the self-incompatibility locus of Rosaceae
(2012)Self-incompatibility (SI) is a major mechanism that prevents inbreeding in ow-ering plants, which was identi ed in Rosaceae, Solanaceae and Scrophulariace. In these families, SI is gametophytic and retains inter-speci ... -
A forensic analysis of genetic variation in the Botswana population
(University of the Western cape, 2016)This thesis has been placed under a long term embargo. Forensic and population genetic parameters were investigated in the Botswana population using autosomal and Y-chromosome short tandem repeat markers. AmpFlSTR Profiler ... -
Functional genomic characterization of fruit quality traits in apple (Malus x domestica Borkh)
(University of the Western Cape, 2009)The domesticated apple (Malus x domestica Borkh), belonging to the Malusgenus of the Rosaceae family, is one of the edible pomaceous fruits. Since it is one of the important commercial fruit crops worldwide, the quality ... -
Genetic mapping of fruit quality traits in apple (malus x domestica borkh.)
(University of the Western Cape, 2011)Apple fruit quality is of utmost importance to apple farmers and breeders in the selection and commercialization of new cultivars. Fruit size, colour, texture, firmness and taste are all traits that affect the quality of ... -
Genome-wide identification and comprehensive analysis of transcriptionsl desert regions
(University of the Western Cape, 2009)The initiation of transcription in mammalian genomes predominatly occurs at 5' promoter regions, however increasingly initiation events have been observed within introns, coding exons and 3' UTRs. Nevertheless there ... -
Genomic and proteomic analysis of drought tolerance in Sorghum (Sorghum bicolor (L.) Moench)
(University of the Western Cape, 2014)Drought is the most complex phenomenon that remained to be a potential and historic challenge to human welfare. It affects plant productivity by eliciting perturbations related to a pathway that controls a normal, ... -
Genomic diversity and functional analysis of the solute carrier genes within indigenous African and Cape Admixed populations
(University of the Western Cape, 2016)Solute carrier transporters belonging to the major facilitator family of membrane transporter are increasingly being recognized as a possible mechanism to explain inter-individual variation in drug efficacy and response. ... -
Green synthesis and characterization of gold nanoparticles from South African plants and their biological evaluations
(University of the Western Cape, 2019)The field of nanotechnology continues to offer solutions for biotechnologists whose target is to improve the quality of life by finding new therapies to combat diseases. Gold nanoparticles (AuNPs) have been showing great ... -
Identification and characterisation of a novel gene, DWNN, isolated from promoter-trapped Chinese hamster ovary cells
(University of the Western Cape, 2005)The process of cytotoxic T lymphocyte (CTL) killing involves the recognition and destruction of foreign antigens by cytotoxic T cells and is of crucial importance to the defence of the organism against viral infections. ... -
Identification and Molecular validation of Biomarkers for the accurate and sensitive diagnosis of bacterial and viral Pneumonia
(University of Western Cape, 2019)Pneumonia remains the major cause of death in children and the elderly and several efforts have been intensified to reduce the rate of pneumonia infection. The major breakthrough has been the discovery of certain biomarkers ... -
Identification of bacterial pathogenic gene classes subject to diversifying selection
(University of the Western Cape, 2009)Availability of genome sequences for numerous bacterial species comprising of different bacterial strains allows elucidation of species and strain specific adaptations that facilitate their survival in widely fluctuating ... -
Identification of differentially expressed proteins in obese rats fed different high fat diets using proteomics and bioinformatics approaches
(2013)Obesity is a medical condition in which an energy imbalance leads to excessive accumulation of body fat. Obesity leads to a reduction in life expectancy through its association with chronic diseases of lifestyle. The ... -
Identification of miRNA's as specific biomarkers in prostate cancer diagnostics : a combined in silico and molecular approach
(University of the Western Cape, 2015)There are over 100 different types of cancer, and each of these cancers are classified by the type of cell that it initially affects. For the purpose of this research we will be focussing on prostate cancer (PC). Prostate ... -
Identification of ruantitative trait loci controlling the requirement for chilling in vegetative budbreak in apple (Malus x domestica Borkh.)
(2008)The domesticated apple (Malus x domestica Borkh.) has been distributed into diverse climatic conditions worldwide for commercial production of fruit. Apple trees need exposure to cold temperatures, referred to as chill ...