Browsing Philosophiae Doctor - PhD (Biotechnology) by Author "Pretorius, Ashley"
Now showing items 1-6 of 6
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Analysis, expression profiling and characterization of hsa-miR-5698 target genes as putative dynamic network biomarkers for prostate cancer: a combined in silico and molecular approach
Lombe, Chipampe Patricia (University of the Western Cape, 2019)2018, the International Agency for Research on Cancer (IARC) estimated that prostate cancer (PCa) was the second leading cause of death in males worldwide. The number of deaths are expected to raise by 50 % in the next ... -
The detection of meningococcal disease through identification of antimicrobial peptides using an in silico model creation
Abdullah, Gadija (University of the Western Cape, 2019)Neisseria meningitidis (the meningococcus), the causative agent of meningococcal disease (MD) was identified in 1887 and despite effective antibiotics and partially effective vaccines, Neisseria meningitidis (N. meningitidis) ... -
Identification and Molecular validation of Biomarkers for the accurate and sensitive diagnosis of bacterial and viral Pneumonia
Bakare, Olalekan Olanrewaju (University of Western Cape, 2019)Pneumonia remains the major cause of death in children and the elderly and several efforts have been intensified to reduce the rate of pneumonia infection. The major breakthrough has been the discovery of certain biomarkers ... -
Identification of miRNA's as specific biomarkers in prostate cancer diagnostics : a combined in silico and molecular approach
Khan, Firdous (University of the Western Cape, 2015)There are over 100 different types of cancer, and each of these cancers are classified by the type of cell that it initially affects. For the purpose of this research we will be focussing on prostate cancer (PC). Prostate ... -
In silico and molecular validation of identified putative genes and functional analysis of a N K G2D ligand as a breast cancer biomarkers
Bankole, Habeeb Adebodun (University of the Western Cape, 2015)The current diagnostic, prognostic, predictive and therapeutic monitoring methods used for breast cancer are limited. Thus, research into more specific, sensitive and effective strategies is required. Breast cancer is ... -
MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches
Fadaka, Adewale Oluwaseun (University of the Western Cape, 2019)Colorectal cancer (CRC) is referred to as cancers that arise in the colon or rectum. Rectal cancer is most often defined as cancers originating within 15 cm from the anal verge. The crude incidence of CRC in sub-Sahara ...