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Aptamer selection against GFRa1 for its application in the prognosis of breast cancer
(University of the Western Cape, 2019)
Breast cancer is the second most common cancer amongst South African women. Despite
ongoing efforts to combat breast cancer, current prognostic and/or therapeutic monitoring
methods are limited since very little improvement, ...
The detection of meningococcal disease through identification of antimicrobial peptides using an in silico model creation
(University of the Western Cape, 2019)
Neisseria meningitidis (the meningococcus), the causative agent of meningococcal disease (MD) was identified in 1887 and despite effective antibiotics and partially effective vaccines, Neisseria meningitidis (N. meningitidis) ...
Proteomic and functional characterisation of biofilm formation in Xylophilus ampelinus
(University of the Western Cape, 2019)
Xylophilus ampelinus, the causal agent of bacterial blight of grapevine, inhabits the vascular tissues
of infected plants where the cells appear to form assemblages resembling biofilms. Bacterial blight
of grapevine ...
Validation and application of a highly discriminating and rapid 10-locus Y-STR DNA profiling system
(University of the Western Cape, 2019)
DNA profiling the male specific region on the Y-chromosome is fundamental to forensic practise. Its recognised as a powerful analytical tool for investigation of sexual assault when the DNA evidence is highly admixed. ...
Analysis, expression profiling and characterization of hsa-miR-5698 target genes as putative dynamic network biomarkers for prostate cancer: a combined in silico and molecular approach
(University of the Western Cape, 2019)
2018, the International Agency for Research on Cancer (IARC) estimated that prostate cancer (PCa) was the second leading cause of death in males worldwide. The number of deaths are expected to raise by 50 % in the next ...
MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches
(University of the Western Cape, 2019)
Colorectal cancer (CRC) is referred to as cancers that arise in the colon or rectum. Rectal cancer
is most often defined as cancers originating within 15 cm from the anal verge. The crude
incidence of CRC in sub-Sahara ...
Green synthesis and characterization of gold nanoparticles from South African plants and their biological evaluations
(University of the Western Cape, 2019)
The field of nanotechnology continues to offer solutions for biotechnologists whose
target is to improve the quality of life by finding new therapies to combat diseases.
Gold nanoparticles (AuNPs) have been showing great ...
Identification and Molecular validation of Biomarkers for the accurate and sensitive diagnosis of bacterial and viral Pneumonia
(University of Western Cape, 2019)
Pneumonia remains the major cause of death in children and the elderly and several efforts have been intensified to reduce the rate of pneumonia infection. The major breakthrough has been the discovery of certain biomarkers ...