School of Pharmacy
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Investigation of common deficiencies observed in scientific assessments and the implementation of a new robust review pathway, the risk-based assessment approach, by the South African Health Regulatory Authority, SAHPRA
(University of the Western Cape, 2022)The main objective of this study is to improve patient access to medicines. The research is two-fold, the first component promotes transparency between the South African Health Products Regulatory Authority (SAHPRA), ... -
An investigation into the impact of training pharmacists' assistants in early recognition and referral procedures on tuberculosis referral rates in the Cape Town metropole
(University of the Western Cape, 2009)Due to the resurgence of TB globally, in 2006 the WHO and the STOP-TB partnership launched a Global plan to STOP TB. This is a l0 year plan which aims to save l4 million lives between 2006 and 2015. Specific targets were ... -
The evaluation of markers for quality control studies of flavonoid-containing medicinal preparations
(University of the Western Cape, 2004)Medicinal plant products in various forms have been available for the treatment of disease in both developing and developed countries for many years (Chan, 2003). Indigenous knowledge on the use of two plants, Artemisia ... -
Investigation of suitable microencapsulation techniques in the preformulation of selected antiretroviral drugs
(University of the Western Cape, 2022)Background: The use of antiretroviral drugs (ARVDs) in the treatment of HIV/AIDS have been promising and effective especially amongst adults as it suppresses the viral load, thereby improving the life expectancy of HIV ... -
Pharmacological evaluation of the medicinal plants, pelargonium triste (l), elytropappus rhinocerotis (l.f), and olea europaea africana (mill.) for antidiarrhoeal activity in mice
(University of the Western Cape, 2001)Three medicinal plant species, Pelargonium triste (L.), Elytropappus rhinocerof,s (L.F.), and Olea europaea africana (Mill.), commonly used in the Western Cape traditional medicine to treat various ailments were assessed ... -
Syndromic treatment of sexually transmitted infections: a western cape community pharmacist study
(University of the Western Cape, 2001)This cross-sectional survey of 85 randomly selected community pharmacists in the Western Cape, South Africa. estimates that 200 000 sexually transmitted infections (STl) cases are seen in private community pharmacies ... -
Factors affecting the pharmacokinetics of vancomycin in children admitted to the intensive care unit (icu) of the Red Cross War Memorial Children's Hospital (RCWMCH).
(University of the Western Cape, 2023)Vancomycin is a glycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminal end of cell wall precursor units preventing the elongation and cross-linkage of the ... -
An evaluation of the Bronchodilator properties of Mentha longifolia and Artemisia afra, traditional medicinal plants used in the Western Cape.
(University of the Western Cape, 2002)The overall objective of this study was to investigate the claims that Mentha longifulia (ML) and Artemisia afra (AA) have anti-asthmatic properties. To realize this objective we were to determine the effects that the ... -
The implementation of the African union model law on medical products regulation and the establishment of the African medicines agency
(University of the Western Cape, 2023)Within Africa, there is insufficient access to quality, safe, efficacious and affordable medical products which can partly be attributed to lack of robust regulatory systems, a lack of competent regulatory professionals ... -
Assessing the influence of electronic media on student perceptions towards antibiotic resistance
(University of the Western Cape, 2023)Antimicrobial resistance (AMR) and the reduced number of new antibiotic discoveries impose a major threat to the quality of human life and effective treatment options. Antibiotic resistant infections require prolonged ... -
A comparison between estimated renal function from point-of care derived cystatin c measurements and serum creatinine derived measurements
(University of the Western Cape, 2023)Serum Creatinine (SCr) is the most commonly used and cost effective biomarker used to quantify estimated glomerular filtration rate. However, creatinine is affected by anthropometric parameters such as muscle mass, age ... -
Evaluation of selected polycyclic compounds as resistance modulators in Mycobacterium tuberculosis
(University of the Western Cape, 2023)Progressive development of resistance to various chemotherapeutic agents used in the management of infectious diseases presents a serious problem in global public health. Increasing levels of antimicrobial resistance in ... -
Formulation and evaluation of tablets manufactured from Dodonaea Angustifolia plant material
(University of the Western Cape, 2001)The liquid dosage form is the most frequently used form for traditional plant medicines. However, this dosage form is associated with many problems, e.g. physicochemical instability, microbial contamination, etc. which may ... -
Synthesis and characterisation of biomimetic immunostimulatory lipid-polymer hybrid nanoparticles
(University of the Western Cape, 2023)Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis), remains a fatal infectious disease and one of the top ten leading causes of mortality, particularly in developing countries. Current drug therapy ... -
Evaluation of the pulmonary effects of the traditionally prepared Artemisia afra steam inhalation and nebulized aqueous extract and the possible involvement of flavonoid luteolin
(University of the Western Cape, 2006)Artemisia afra is a popular medicinal plant traditionally used to treat respiratory conditions such as asthma, bronchitis etc., most frequently as a steam inhalation. The effectiveness of this steam inhalation, its active ... -
The influence of the proposed professional fee for community pharmacists on prescription income
(University of the Western Cape, 2002)prescription pricing in community pharmacies in South Africa involves a percentage mark-up on the cost of the product, followed by a varying discount to either the client or the medical scheme. The Pharmaceutical Society ... -
Homology modelling and characterization of three-dimensional (3d) protein structures of selected variants of cyp3a4
(University of the Western Cape, 2022)The efficacy and toxicity of several drugs and prodrugs are influenced by the interindividual genetic variations in drug-metabolising enzymes. Cytochrome P450 enzymes constitute the major metabolising enzymes in humans. ... -
Determination of plasma concentrations using Lc/ms and pharmacokinetics of ofloxacin in Patients with multi-drug resistant tuberculosis and In patients with multi-drug resistant tuberculosis co- Infected with hiv
(University of the Western Cape, 2009)Many studies have investigated the pharmacokinetics of anti-tuberculosis drugs in patients infected with tuberculosis. However, little is known about the pharmacokinetics of the drugs that are used in the treatment of ... -
The use of Dioxy MP 14 (stabilized aqueous chlorine dioxide) to control environmental airborne microorganisms
(University of the Western Cape, 2009)Dioxy MP 14 is a locally developed form of stabilized chlorine dioxide in an aqueous medium. It has all the sanitizing properties of chlorine dioxide gas, a neutral compound of chlorine in the +IV oxidation state, which ... -
Antiasthmatic properties of Lippia javanica and Myrothamnus flabellifolius using an in vitro model
(University of the Western Cape, 2022)Asthma is a reversible, chronic inflammatory disease that causes obstruction to the airways that causes an increase in airway hyperresponsiveness that leads to recurrent episodes of chest tightness and coughing. Lippia ...
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