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The impact of nanoparticles on the proteome of cultured human cells
(2021)
Living organisms are constantly being exposed to nanoparticles (NPs) in the environment via air,
water, soil. Routes of exposure are usually in the form of industrial, occupational exposure, as well
as therapeutic ...
The characterisation of human coronavirus nl63 proteins
(University of Western Cape, 2021)
Human Coronavirus NL63 (HCoV-NL63) is one of seven coronaviruses (CoVs) that cause respiratory disease in the global population. The Membrane (M) and Nucleocapsid (N) proteins are part of the core CoV-structural proteins, ...
Radiation-induced leukaemia in South Africa: response of lymphocytes and cd34+ cells to different radiation qualities.
(University of the Western Cape, 2020)
Epidemiological studies have highlighted that leukaemia can be considered as the most prominent malignancy after radiation exposure during childhood. The lifetime risk on radiation-induced leukaemia for a given dose is 3 ...
Typha capensis—An electron rich resource for the synthesis of phytochemical-encapsulated gold nanoparticles through green nanotechnology
(University of the Western Cape, 2020)
Typha capensis (T. capensis), commonly known as bulrush, is a medicinal plant found growing in the wetland areas of South Africa. In traditional medicine, rhizome decoctions of T. capensis are used to treat a wide variety ...
The effects of various combinations of different Cdasses of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 and triple-negative MDA-MB 231 breast carcinoma cell lines
(University of the Western Cape, 2020)
Globally, breast cancer is the most common cancer affecting women and it is predicted that in 2030 about 12 million deaths will occur with approximately 21.7 million new cases [2]. Genetic risk factors as well as race and ...
Radiation-induced Leukaemia in South Africa: Response of lymphocytes and cd34+ cells to different radiation qualities
(University of the Western Cape, 2020)
Epidemiological studies have highlighted that leukaemia can be considered as the most prominent malignancy after radiation exposure during childhood. The lifetime risk on radiation-induced leukaemia for a given dose is 3 ...
Differential toxicity of two murine endothelial cells to ROS duress: Understanding oxidative stress-induced blood-brain barrier dysfunction
(University of the Western Cape, 2020)
The blood-brain barrier (BBB) is a critical interface between the blood circulation and brain tissue which performs critical selection of circulating molecules that gain access to the brain tissue. Its unique ability to ...
Cell culture biomarkers for monitoring of wastewater pollutants
(University of the Western Cape, 2021)
Wastewater is normally composed of a mixture of pollutants. The type and composition of pollutants in a particular wastewater depend on the source of origin. The source and characteristics of a particular wastewater determine ...
Optimizing embryo culture conditions and spent culture media analysis as predictors of embryo quality and pregnancy
(University of the Western Cape, 2021)
The aim of this thesis is first, to evaluate various culture conditions to improve embryo development, and secondly, to analyze spent culture media for any biomarkers that may be predictive of embryo health. Single-step ...
The effects of green tea, green rooibos and their major flavonoids (EGCG and aspalathin) on testicular cell health in vitro
(University of Western Cape, 2021)
The testes play a central role in the male reproductive system, as they represent the sites of male sex steroidogenesis and of spermatogenesis. Leydig cells, located at the testicular interstitium, produce predominantly ...