Identification of coding variants associated with familial systemic lupus erythematosus through whole exome sequencing
van Vuuren, Larry Peter
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Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by the production of a wide range of autoantibodies directed against selfantigens. SLE can influence almost any organ system and its appearance and course are highly varied, ranging from remission to disease flare. SLE demonstrates a variety of constitutional symptoms, such as the skin, musculoskeletal and mild hematologic involvement. On the other hand, some patients present with primarily hematologic, renal or neuropsychiatric manifestations.