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Polycyclic propargylamine derivatives as multifunctional neuroprotective agents
(University of the Western Cape, 2018)
The abnormal death of neurons in the central nervous system of individuals suffering from neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis, ...
Investigating the anti-cancer activity of novel phenothiazines in glioblastoma
(University of the Western Cape, 2018)
Glioblastoma multiforme (GBM) remains the most malignant of all primary adult brain tumours. It is a highly invasive and vascularized neoplasm with limited treatment options and very low survival rate. GBM tumours are ...
Role of Rutin in 1-Mtthyl-4-Phenylpyridinium toxicity: Therapeutic implications for Parkinson's disease
(University of the Western Cape, 2018)
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the
progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain.
Although the etiology of PD is not ...