Search
Now showing items 1-9 of 9
Electrochemical cytochrome P450 enzymatic biosensors for the determination of the reactivity of TB drugs
(University of Western Cape, 2020)
Tuberculosis (TB) remains a global epidemic despite the fact that treatment has been available since the 1950’s. This disease is highly contagious and spreads via transmission of the Mycobacterium Tuberculosis (MTB) tubercle ...
The physicochemical characterisation, compatibility testing and solid-state form screening of terizidone - Pyridoxine combinations
(University of Western Cape, 2021)
Terizidone (TZD) is considered an essential anti-tuberculosis drug and in South
Africa it is prescribed as part of the multi-drug resistant tuberculosis (MDR-TB) treatment
regimen. From a literature study it became ...
Selected antiretroviral and anti-tuberculosis drug combinations by non-covalent bonding
(University of Western Cape, 2021)
Treatment of the human immunodeficiency virus (HIV) and tuberculosis (TB) infections have become very complicated due to the advent of drug resistance. Drug combinations offer an alternative approach to reducing the emergence ...
Development of rifampicin loaded in surface-modified 4.0 G PAMAM dendrimer as a novel antituberculosis pulmonary drug delivery system
(University of the Western Cape, 2020)
Introduction: Tuberculosis (TB) is a serious bacterial infections caused by the Mycobacterium Tuberculosis (MTB) organism affecting mainly the lungs. Occasionally, MTB bacilli may be transported out of the pulmonary region ...
Gold nanoparticulate modified thioglycolic acid (tga) phenotype nanobiosensor for tuberculosis drugs
(University of the Western Cape, 2022)
Tuberculosis (TB) carries on being a major global health issue and it is responsible for 1.5 million disease-related mortality in 2020, according to the World Health organisation (WHO). One of the major causes of death ...
Synthesis and characterization of magneto-electric nanoparticles for delivery of antituberculosis drugs across the blood-brain barrier
(University of the Western Cape, 2022)
The anatomical structure of the brain at the blood–brain barrier (BBB) creates a limitation for the
movement of drugs into the central nervous system (CNS). Although anti-infective drugs effective
against Mycobacterium ...
Synthesis and characterisation of biomimetic immunostimulatory lipid-polymer hybrid nanoparticles
(University of the Western Cape, 2022)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis),
remains a fatal infectious disease and one of the top ten leading causes of mortality,
particularly in developing countries. Current drug therapy ...
Evaluation of selected polycyclic compounds as resistance modulators in Mycobacterium tuberculosis
(University of the Western Cape, 2022)
Progressive development of resistance to various chemotherapeutic agents used in the management
of infectious diseases presents a serious problem in global public health. Increasing levels of
antimicrobial resistance in ...
Carbon dot – polythionine nanocomposite sensor for the remediation of antibiotics in water
(University of the Western Cape, 2022)
Antibiotics are a necessary part of the world today where their main purpose is to
counter bacteria and diseases. Antibiotics are used in many areas which include
apiculture, domestic, livestock and medically. Since ...