Now showing items 1-3 of 3
Development and characterization of pro-apoptotic drug candidates for anticancer drug discovery
Cancer is one of the leading causes of death worldwide. According to the WHO, cancer accounted for 7.4 million deaths world wide in 2004. The metallo-compound cisplatin has been used for years as an effective antitumor ...
Role of Rutin in 1-Mtthyl-4-Phenylpyridinium toxicity: Therapeutic implications for Parkinson's disease
(University of the Western Cape, 2018)
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Although the etiology of PD is not ...
Differential toxicity of two murine endothelial cells to ROS duress: Understanding oxidative stress-induced blood-brain barrier dysfunction
(University of the Western Cape, 2020)
The blood-brain barrier (BBB) is a critical interface between the blood circulation and brain tissue which performs critical selection of circulating molecules that gain access to the brain tissue. Its unique ability to ...