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dc.contributor.advisorvan der Horst, Gerhard
dc.contributor.authorMdhluli, Mongezi
dc.date.accessioned2021-11-10T12:47:26Z
dc.date.available2021-11-10T12:47:26Z
dc.date.issued2003
dc.identifier.urihttp://hdl.handle.net/11394/8564
dc.descriptionPhilosophiae Doctor - PhDen_US
dc.description.abstractIntroduction: Plant extracts and herbal preparations are often marketed as natural and safe alternatives to conventional medicines for the prevention and treatment of a variety of ailments, without proof of efficacy and safety. Cardiovascular, hematopoetic, hepatic and renal impairment resulting from the use of conventional drugs is widely acknowledged. However, there is less awareness of the potential toxicity of herbal preparations and other botanicals, many of which are widely perceived by the public as being effective and harmless, and are commonly used for self medication without supervision. In addition, potential interactions between herbal medicines and conventional drugs may compromise with patient management. In the safety evaluation of most substances, non human primates are preferred to rodent species for preclinical animal safety studies, because of their biological similarity to humans. They are regarded to be the best metabolic models for humans in a broad range of investigations. Additionally, a disadvantage of using small animal species in toxicological testing is that they require higher doses of drugs and more frequent administrations than in larger species. In light of these considerations, vervet monkeys are used here to investigate toxicity of a plant-derived triterpene, oleanolic acid. The focus is to determine effects of different concentrations of this triterpene on the cardiovascular, hematopoetic, hepatic and renal systems. Materials and methods: 12 male vervet monkeys used in this study were equally divided into four groups, i.e. three treatment groups (4, 10 and 25 mg/kg bodyweight), and one control group. Each individual in a treatment group received a specified concentration of oleanolic acid in food for 16 weeks. Monkeys in the control group received the vehicle (food) alone. Bodyweight, body temperature, respiratory rate, heart rate, systolic pressure, diastolic pressure, and mean arterial pressure were recorded from ketamine-anaethetized monkeys at baseline and every second week until week 16.en_US
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.subjectHepatoprotectiveen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAnti-tumoren_US
dc.subjectAnti-ulceren_US
dc.subjectAnti-microbialen_US
dc.subjectHypoglycemicen_US
dc.subjectad libitumen_US
dc.subjectChlorocebus aethiopsen_US
dc.subjectHematopoeticen_US
dc.subjectVerveten_US
dc.subjectOleanolicen_US
dc.titleToxicological and antifertility investigations of oleanolic acid in male vervet monkeys (chlorocebus aethiops)en_US
dc.rights.holderUniversity of the Western Capeen_US


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