Browsing Magister Scientiae - MSc (Medical BioSciences) by Title
Now showing items 97-116 of 160
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The influence of maternal nicotine exposure on neonatal rat lung septal status
(University of the Western Cape, 1995)The aim of this study was to determine the effect of maternal nicotine exposure on the status of rat lung alveolar septa of 1 to 2l day old offspring. Wistar dams were injected subcutaneously, using a dosage of 1 mg ... -
The integrated effects of selected inducers of endoplasmic reticulum stress, the unfolded protein response and apoptosis on P-Glycoprotein mediated drug resistance in MCF-7 breast carcinoma cells
(University of the Western Cape, 2015)Purpose: One of the leading causes of death reported in women worldwide is breast cancer. Manytumours, including breast cancer, associated with poor prognosis, have received a renewed focus and increased perspective with ... -
The interaction between 6 MV X-rays and p(66)/Be neutrons with spherical gold nanoparticles to induce cellular damage
(University of the Western Cape, 2016)Despite the advances in therapies such as chemotherapy and radiotherapy, tumours have been shown to be resistant to the treatments. Gold nanoparticles (AuNPs) have been recognized as effective radiosensitizers of low energy ... -
Investigating effects of aqueous root extract of Mondia whitei on sperm functionality
(University of the Western Cape, 2016)Introduction: Mondia whitei commonly known as "White Ginger" is a highly acclaimed medicinal plant that is extensively used across Africa. M. whitei is used as treatment for sexual dysfunction and is considered to be an ... -
Investigating factors that influence the breeding success of the endangered African penguin (Spheniscus demersus) at a mainland and island colony in the Western Cape, South Africa
(University of Western Cape, 2022)Since the 1950s the global seabird population have declined by 70% and today some penguin species are amongst the most threatened seabirds in the world. The African penguin (Spheniscus demersus) population experienced a ... -
Investigating hypoglycaemic effects and safety of the herbal Product – JT2016 in vivo study
(University of the Western Cape, 2021)Diabetes has since been a global epidemic; an estimated 5.0 million deaths of diabetes in the world have been recorded; one in 11 adults have diabetes (415 million); and by 2040, one adult in 10 (642 million) will have ... -
Investigating hypoglycaemic effects and safety of the herbal product – jt2016 in vivo study
(University of the Western Cape, 2021)Diabetes has since been a global epidemic; an estimated 5.0 million deaths of diabetes in the world have been recorded; one in 11 adults have diabetes (415 million); and by 2040, one adult in 10 (642 million) will have ... -
Investigating novel aspects of the blood-brain barrier using high resolution electron microscopy
(University of the Western Cape, 2022)The blood-brain barrier (BBB) is a restrictive interface located between the blood circulation and the central nervous system (CNS), regulating the homeostatic environment of the neuronal milieu, by controlling the ... -
Investigating the relationship between iron deficiency and depressive symptoms in relation to the body compositions of students residing in the Western Cape
(University of the Western Cape, 2022)Iron deficiency is the consequence of a prolonged diminished iron balance, whereby iron stores are no longer sufficient to meet the requirements of regular iron turnover. It is the most ubiquitous single nutrient deficiency, ... -
Investigation of some possible mechanisms involved in the anticonvulsant activity of Tulbaghia violacea harv
(University of the Western Cape, 2015)Even though Tulbaghia violacea has been used to treat and manage epilepsy in South Africa by traditional medicine practitioners, no evidence in any literature has shown any scientific scrutiny of the effectiveness of the ... -
Investigations on the in vitro effects of aqueous Eurycoma longifolia Jack extract on male reproductive functions
(University of Western Cape, 2012)Introduction: Eurycoma longifolia (Tongkat Ali; TA) is a Malaysian shrub used to treat various illnesses including male infertility. Considering that TA is also used to improve male fertility and no report regarding ... -
Liposomal drug delivery to brain cancer cells
(University of the Western Cape, 2015)Neuroblastomas (NBs) are the most common solid extra-cranial tumours diagnosed in childhood and characterized by a high risk of tumour relapse. Like in other tumour types, there are major concerns about the specificity and ... -
lnvestigations into the cancer modulating properties of Aspalathus linearis (Rooibos), Cyclopia intermedia (Honeybush) and Sutherlandia frutescens (Cancer bush) in oesophagea! carci nogenesis
(University of the Western Cape, 2007)This thesis contains scientific evidence on the anticancer properties of two unique South African herbal teas, rooibos and honeybush, and the herbal plant Sutherlandia frutescens (cancer bush) using an in vivo oesophageal ... -
Maternal nicotine expose during gestation and lactation induce premature aging of the lungs of the offspring
(University of the Western Cape, 2009)Tobacco smoking remains one of the leading causes of death worldwide. Despite all the efforts made by governments, researchers and communities to educate women about the dangerous effects of tobacco smoke and nicotine, ... -
Medicinal uses of Galenia africana: A study of the antimicrobial, antifungal and anticancer properties
(University of the Western Cape, 2018)Medicinal uses of Galenia africana: A study of the antimicrobial, antifungal and anticancer properties Over the years, microorganisms have become resistant to commonly used antimicrobial agents leading to multidrug resistance. ... -
Mercury leaching from dental amalgam fillings and its association with urinary zinc
(University of the Western Cape, 2019)Mercury (Hg) is an example of a toxic metal that is not essential for nutrition. It exists in organic and inorganic forms in seafood and vapour from dental amalgam fillings respectively. Elemental mercury (Hg0) from dental ... -
Microscopic analysis of In vitro and In vivo effects of functionalized gold nanoparticles on the liver, kidney, spleen, heart and pancreas of male wistar rats
(University of the Western Cape, 2022)Nanotechnology represents a promising knowledge based platform that can solve human needs and ailments, especially in cases like cancers, diabetes, antibiotic drug resistances etc. Many metallic nanoparticles are being ... -
The modulating effect of conjugated linoleic acid (CLA) on cancer cell survival in vitro
(University of the Western Cape, 2014)Conjugated linoleic acids (CLA) are geometrical and positional isomers of n-6 octadecadenoic acid (linoleic acid, LA, 18:2n-6), which form part of a family of essential polyunsaturated fatty acids (PUFA). There are 28 ... -
The modulating effect of fatty acids on the lipid profile in colon epithelial mucosa in Vivo
(University of the Western Cape, 2009)Several abnormal conditions, including some cancers, have been associated with changes in the membrane lipid and FA composition. Dietary fat serves as a major source of lipids and FA, particularly the polyunsaturated fatty ... -
Molecular genetics: strategies to identify congenital cataract genes in captive-bred vervet monkeys
(University of the Western Cape, 2013)Molecular genetics: strategies to indentify congenital cataract genes in captive-bred Vervet monkeys Zandisiwe Emilia Magwebu MSc thesis, Department of Medical Biosciences, University of the Western Cape The present ...