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Now showing items 61-70 of 93
The effects of selective inhibitors of n-glycosylation and endoplasmic reticulum stress inducers on the expression of neuroblastoma drug resistance
(University of the Western Cape, 2017)
Neuroblastoma (NB) represents 8-10% of all childhood tumours and accounts for
approximately 15% of all cancer-related deaths in the paediatric population. Approximately
half of newly diagnosed children with this tumour ...
The use of whole blood cell cultures as a model for assessing the effects of Septilin on the immune system
(University of the Western Cape, 2017)
In the past three decades there has been a huge increase in the use of herbal medicine globally.
The active principles of these herbal medicines are mostly unknown with supportive evidence for
safety and efficacy very ...
Examination of the biocompatibility and anti-microbial activity of coated dental implants
(University of the Western Cape, 2017)
Teeth are important to all people for chewing, speech and aesthetics. Tooth decay,
periodontal disease and physical trauma or injuries are the main causes of tooth
loss. There are different forms of treatment for tooth ...
The effect of methamphetamine on the blood-testis barrier
(University of the Western Cape, 2018)
Introduction
The blood-testis barrier (BTB) is formed by tight junctions between adjacent Sertoli cells. The barrier formed by these tight junction helps to create a specialized environment for spermatogenesis and provide ...
Formulation and evaluation of the biocompatibility of chitosan-dextran nanoparticles using a blood-brain barrier model
(University of the Western Cape, 2018)
Central nervous system (CNS) infections are a therapeutic challenge. This is partly due to insufficient drug penetration across the blood-brain barrier (BBB). The BBB is a specialized, highly selective, metabolically active ...
Evaluation of sperm functionality in non-human primates, focussing on sperm capacitation
(University of the Western Cape, 2019)
The incidence of male infertility is increasing, with up to 50% of infertile males having “unexplained” (idiopathic) infertility. Newly developed molecular techniques have great value in detecting subtle causes of male ...
The efficiency of drinking water treatment plants in removing immunotoxins
(University of the Western Cape, 2010)
The aim of this study was to evaluate the effectiveness of water treatment processes of two drinking water plants to remove immunotoxins and steroid hormones. Raw and treated drinking water was screened for effects on ...
Effects of graphene oxide nanoparticles on the immune system biomarkers produced by RAW 264.7
(University of the Western Cape, 2019)
Graphene oxide (GO) is a single carbon layer, oxygen bearing graphene derivative, containing hydroxyl and carboxyl groups. Graphene oxide nanoparticles (GONPs) are promising nanomaterials for a variety of applications such ...
Brine shrimp lethality test and acetylcholine esterase inhibition studies on selected South African medicinal plants
(University of the Western Cape, 2012)
Research into traditional medicines is often conducted in a multidisciplinary approach as motivated by a desire to understand them in as complete a manner as possible,realizing their chemistry, biology and pharmacology. ...
The role of the glutathione system in regulating the levels of ROS neutralisation in the endothelial cells of the blood-brain barrier
(University of the Western Cape, 2017)
Brain endothelial cell types are frequently used as in vitro models to study the
blood-brain barrier (BBB). Oxidative stress (OS) has been reported numerous times
to cause BBB dysfunction which is crucial to the initiation ...