Browsing by Author "Joubert, Jacques"
Now showing items 1-13 of 13
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Additional regulatory review pathways can facilitate faster dossier approvals in South Africa
Mattew, Ilona (University of the Western Cape, 2019)The objective of the study was to perform a comparative review of pathways, timelines and improvements of countries with markets that the South African Health Products Authority (SAHPRA) benchmark themselves against. ... -
Chalcone and curcumin hybrids of indole propargylamines as multifunctional neuroprotective agents
Musakwa, Lovetone (University of the Western Cape, 2020)Neurodegenerative disorders (NDs) are a range of chronic brain disorders that includes amongst others motor function loss. Parkinson’s disease (PD) is one of the common NDs that has an insidious onset and diagnosed when ... -
Discovery of heat shock protein90 inhibitors using structured-based virtual screening
Ngcagawule, Siyasanga (University of the Western Cape, 2023)Alzheimer's disease (AD) is the most common irreversible dementia, caused by accumulation of protein aggregates in the central nervous system, with symptoms that include memory loss and behavioural abnormalities. Cholinesterase ... -
Investigation of common deficiencies observed in scientific assessments and the implementation of a new robust review pathway, the risk-based assessment approach, by the South African Health Regulatory Authority, SAHPRA
Moeti, Lerato Petunia (University of the Western Cape, 2022)The main objective of this study is to improve patient access to medicines. The research is two-fold, the first component promotes transparency between the South African Health Products Regulatory Authority (SAHPRA), ... -
Novel adamantane-chloroquinolin conjugates to overcome plasmodium falciparum chloroquine resistance
Yvette, Mofenge Opute (University of the Western Cape, 2017)Malaria poses devastating health and socioeconomic outcomes on global health especially among pregnant women and children below the age of 5 in endemic areas. This is exacerbated by Plasmodium falciparum resistance to ... -
Novel norbornane derivatives as potential neuroprotective agents
Egunlusi, Ayodeji Olatunde (University of Western Cape, 2020)Neurodegenerative disorders are characterised by progressive loss of the brain’s physiological functions as a result of gradual degeneration of neurons in the central nervous system. Even though they are classified as ... -
Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection
Egunlusi, Ayodeji Olatunde (University of the Western Cape, 2014)This study focused on the synthesis of a series of novel tricycloundecane derivatives and evaluation of these compounds for neuroprotection using the fluorescent ratiometric calcium assay that indicates the ability of the ... -
Polycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugs
Abaniwonda, Modupe (University of the Western Cape, 2017)Recent scientific findings have highlighted the beneficial roles of polycyclic cage compounds in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Further interest into the chemistry of these compounds ... -
Polycyclic propargylamine derivatives as multifunctional neuroprotective agents
Zindo, Frank T. (University of the Western Cape, 2018)The abnormal death of neurons in the central nervous system of individuals suffering from neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis, ... -
Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
Pokomi, Rostand Fankam (University of the Western Cape, 2020)Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are ... -
A supramolecular derivatised study of BIS(Adamantan-1- Aminium) carbonate
Ngilirabanga, Jean Baptiste (University of the Western Cape, 2014)In this study, new solid supramolecular derivatised forms of bis(adamantine-1-aminium) carbonate (ADTCO3) were prepared. ADTCO3 is a derivative of amantadine used for Parkinson’s disease and has antiviral properties against ... -
Synthesis & biological evaluation of neuroprotective molecules with polycyclic scaffolds
Sharma, Rajan (University of the Western Cape, 2017)Among neurological disorders, many of the most devastating disorders are neurodegenerative. Modern research associates excitotoxicity to a variety of neuropathological conditions, suggesting that the neurodegenerative ... -
Synthesis and evaluation of 7-substituted 3-propargylamine coumarin derivatives as multifunctional monoamine oxidase and cholinesterase inhibitors for Alzheimer’s Disease treatme
Mzezewa, Sheunopa C. (University of Western Cape, 2020)Alzheimer’s Disease (AD) is a neurodegenerative disease which results from the irreversible loss of neurons in the brain. The disease is characterized by progressive cognitive impairment with recurrent short-term memory ...