Green synthesis and characterization of silver nanoparticles from the cocktail of capparis sepiaria-tabernaemontana elegans extracts and assessment of their biological effects in vitro.

Abstract

Antimicrobial Resistance (AMR) is a global crisis that develops when bacteria, viruses, fungi, and parasites adapt and multiply in the presence of drugs that once negatively affected them. AMR infections are commonly caused by the overuse and misuse of ntimicrobial drugs, thus leading to severe illnesses, longer hospitalization, increased healthcare expenses, treatment ineffectiveness, and increased mortality. The increasing incidence of AMR poses a serious threat to public health. As a result, alternative strategies that are both effective against AMR pathogens and eco-friendly are urgently needed. Green nanotechnology, in particular the use of silver nanoparticles (AgNPs), has been used as a solution in a wide range of applications, including antibacterial, antiviral, and antifungal therapies. Over the last decades, several medicinal plant extracts have been used to synthesize AgNPs; however, combining extracts from two medicinal plants to synthesize AgNPs with enhanced properties has received less attention. Therefore, this study reports on the green synthesis of AgNPs using a cocktail of Capparis sepiaria–Tabernaemontana elegans (CsTe) aqueous extracts as a reducing, stabilizing, and capping agent, and evaluation of their antimicrobial activities.