Magister Scientiae - MSc (Biotechnology)
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Recent Submissions
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Characterization of ATP-binding cassette drug transporters and their role in breast cancer treatment using in silico approach
(University of the Western Cape, 2019)Breast cancer is the most common cancer in women worldwide, and is the second most common cancer in the world, responsible for more than 500 000 deaths annually. Estimates are that 1 in 8 women will develop breast cancer ... -
Green synthesis and characterization of silver nanoparticles (AgNPs) from Bulbine frutescens leaf extract and their antimicrobial effects
(University of the Western Cape, 2020)Combating antimicrobial resistant infections caused by nosocomial pathogens poses a major public health problem globally. The widespread use of broad-spectrum antibiotics for the treatment of wound infections has led to ... -
Development and validation of a pharmacogenomics profiling panel suitable for personalizing Metformin therapy
(University of the Western Cape, 2019)The burden of non-communicable diseases (NCDs) in South Africa is predicted to increase substantially in the next decades if the necessary preventative measures are not taken. The two most common NCDs associated with rapid ... -
Isolation and characterization of stem endophytic bacteria from weed plants for enhancing Vanadium tolerance in Brassica napus
(University of the Western Cape, 2019)Bacterial endophytes are able to improve the growth of their hosts through a number of different mechanisms such as nutrient uptake regulation, plant hormone production and regulation, siderophore production and phosphate ... -
Identification and characterisation of sorghum bicolor heme oxygenase-1 (sbho1) gene and its role in conferring biotic and abiotic stress tolerance to plants
(University of the Western Cape, 2019)Biotic and abiotic stresses such as herbivore attack, pathogen infection, salinity, drought, cold, heat and UV radiation, are unfavourable conditions that affect plant growth and productivity globally (Fedoroff et al., ... -
The geographical analysis of the mitochondrial DNA control region found in southern African population's by using a bioinformatics approach
(University of the Western Cape, 2020)South Africa’s demographic complexity has been historically shaped by interethnic admixture between the native KhoiSan inhabitants and the Bantu expansion that started 3000 - 5000 YBP and reached South Africa about 1000 ... -
Responses of maize antioxidant enzymes to drought stress
(University of the Western Cape, 2019)Maize (Zea mays L) was subjected to drought stress for 28 days. The effects of the drought stress on growth, H2O2 content and lipid peroxidation were investigated and the activities of antioxidant enzymes [superoxide ... -
Development and validation of a pharmacogenomics profiling panel suitable for personalizing metformin therapy
(University of the Western Cape, 2019)The burden of non-communicable diseases (NCDs) in South Africa is predicted to increase substantially in the next decades if the necessary preventative measures are not taken. The two most common NCDs associated with ... -
Responses of maize Antioxidant Enzymes to drought stress
(University of the Western Cape, 2019)Maize (Zea mays L) was subjected to drought stress for 28 days. The effects of the drought stress on growth, H2O2 content and lipid peroxidation were investigated and the activities of antioxidant enzymes [superoxide ... -
Biogenic synthesis of gold nanoparticles using red and green pear fruit extracts
(University of the Western Cape, 2019)There has been a growing interest in the design of biocompatible and environmentally affable nanoparticles (NPs) among scientists to develop novel and safe biomaterials for use in various biomedical applications. This can ... -
Development of an aptamer based lateral flow test strip for a diabetes biomarker
(University of the Western Cape, 2019)Diabetes mellitus is one of the major chronic diseases that poses a significant risk to human health globally. Current diagnostics for diabetes are based on blood glucose measurements, which can go unnoticed for years. ... -
The antimicrobial activity of zinc oxide nanoparticles synthesized with plant extracts against Staphylococcus aureus
(University of the Western Cape, 2019)Nanoparticles using a green synthesis production method is of increasing interest for biomedical applications. Zinc oxide is currently used in medicinal and cosmetic formulations, and zinc oxide nanoparticles have potential ... -
The development of functionalized metallic nanoparticles for the treatment of brain cancer
(University of the Western Cape, 2019)Cancers of the nervous system often result from abnormal and uncontrolled growth of cells in nervous tissue. Glioblastoma Multiforme (GBM) and neuroblastoma (NB) are among the most common nervous system-associated cancers ... -
Bioactivity and genome guided isolation of a novel antimicrobial protein from Thalassomonas viridans
(University of the Western Cape, 2019)The continued emergence of bacterial resistance to the antibiotics currently employed to treat several diseases has added to the urgency to discover and develop novel antibiotics. It is well established that natural products ... -
Novel gold nanoparticles of drought tolerance enabler GYY4137
(University of the Western Cape, 2019)Different nanoparticles have the ability to improve plant tolerance to drought stress. In the study we report for the first time novel morpholin-4-ium 4-methoxyphenyl (morpholino) phosphinodithioate capped- gold nanoparticles ... -
Evaluation of cytotoxic activity of gold nanoparticles naturally synthesised from South African indigenous medicinal plant extracts
(University of the Western Cape, 2018)Nanotechnology has emerged as a promising field in the quest to address health conditions. Green nanotechnology is a fairly new branch of nanotechnology, which aims to produce and utilize nanomaterials in a way that is ... -
Synthesis of silver doped titanium dioxide nanocomposites using tea extract from Aspalathus linearis and evaluation of their antibacterial effects.
(University of the Western Cape, 2018)Despite the wide success of antimicrobial agents against waterborne pathogens, waterborne disease continues to pose a threat to both mankind and animals. A major concern is that certain bacteria have developed resistance ... -
The identification of aptamers against serum biomarkers of human tuberculosis
(University of the Western Cape, 2018)Tuberculosis (TB) is a global health problem and rated as the second leading cause of death after HIV/AIDS. Transmission of TB from one person to the next is very rapid in crowded communities. Therefore, it is crucial to ... -
The effect of blocking selected endocytic mechanisms on heterologous protein secretion in the yeast saccharomyces cerevisiae
(University of the Western Cape, 2018)The yeast Saccharomyces cerevisiae is considered a good host used for heterologous protein production due to the organism’s microbial safety, rapid growth and eukaryotic post- translational processing. As a fermentative ... -
Peptide functionalised gold nanorods for the selective eradication of target cells using photothermal therapy
(University of the Western Cape, 2019)Cancer is one of the leading causes of death, worldwide. Mortality tolls are estimated to reach approximately 13.1 million in 2030. These statistics suggest that current therapeutic strategies are not effective. This is ...
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