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Identification and characterization of microRNAs and their putative target genes in Anopheles funestus s.s
(2013)
The discovery of microRNAs (miRNAs) is one of the most exciting scientific
breakthroughs in the last decade. miRNAs are short RNA molecules that do not encode proteins but instead, regulate gene expression. Over the past ...
Development of a hepatitis C virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
(2011)
To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ...
Observations on the ecology and life-history of Chrysaora fulgida (Reynaud 1830) (Scyphozoa: Semaeostomeae) and other pelagic cnidarians in the inshore waters off central Namibia
(University of the Western Cape, 2019)
Although jellyfish are recognised recently as key components that can influence ecosystem functioning and trophic flows in the northern Benguela upwelling ecosystem, the number of published studies on their abundance, ...
Coding of tsetse repellents by olfactory sensory neurons: towards the improvement and the development of novel
(University of the Western Cape, 2020)
Tsetse flies are the biological vectors of human and animal trypanosomiasis and hence representant medical and veterinary importance. The sense of smell plays a significant role in tsetse and its ecological interaction, ...
Effects of nucleotide variation on the structure and function of human arylamine n-acetyltransferase 1
(2012)
The human arylamine N-acetyltransferase 1 (NAT1) is critical in determining the duration of action and pharmacokinetics of amine-containing drugs such as para-aminosalicylic acid and para-aminobenzoyl glutamate used in ...
Development and implementation of ontology-based systems for mammalian gene expression profiling
(2009)
The use of ontologies in the mapping of gene expression events provides an
effective and comparable method to determine the expression profile of an entire
genome across a large collection of experiments derived from ...
Development of a Hepatitis C Virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
(University of the Western Cape, 2011)
To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ...
An evolutionary genomics approach towards analysis of genes implicated in transmission of trypanosomes between tsetse fly and mammalian host
(2009)
Human African trypanosomiasis is the world’s third most important parasitic disease affecting human health after malaria and schistosomiaisis. The world health organization estimates approximately 60 million people at risk ...
A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
(2009)
Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp)
parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly ...
Development of a comprehensive annotation and curation framework for analysis of Glossina Morsitans Morsitans expresses sequence tags
(University of the Western Cape, 2011)
This study has successfully identified transcripts differentially expressed in the salivary gland and midgut and provides candidate genes that are critical to response to parasite invasion. Furthermore, an open-source ...