Browsing School of Pharmacy by Title
Now showing items 207-225 of 225
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Synthesis and characterisation of biomimetic immunostimulatory lipid-polymer hybrid nanoparticles
(University of the Western Cape, 2022)Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis), remains a fatal infectious disease and one of the top ten leading causes of mortality, particularly in developing countries. Current drug therapy ... -
Synthesis and evaluation of 7-substituted 3-propargylamine coumarin derivatives as multifunctional monoamine oxidase and cholinesterase inhibitors for Alzheimer’s Disease treatme
(University of Western Cape, 2020)Alzheimer’s Disease (AD) is a neurodegenerative disease which results from the irreversible loss of neurons in the brain. The disease is characterized by progressive cognitive impairment with recurrent short-term memory ... -
Synthesis and evaluation of fluorescently linked polycyclic cage derivatives for application in neurodegenerative disorders
(University of the Western Cape, 2020)Neurodegenerative diseases (ND) are chronic and progressive in nature, and characterized by the gradual loss of neurons in various regions of the central nervous system (CNS). ND include Alzheimer's disease (AD), Parkinson's ... -
Synthesis and evaluation of novel coumarin-donepezil derivatives as dual acting monoamine oxidase B and cholinesterase in Alzheimer's disease
(University of the Western Cape, 2016)Alzheimer's disease is a progressive neurodegenerative disease characterised by low acetylcholine (ACh) levels in the hippocampus and cortex of the brain, causing symptoms like progressive memory loss, decline in language ... -
Synthesis and Physicochemical Characterisation of Poly (?-caprolactone) Nanoparticles for Delivery of Propranolol
(University of the Western Cape, 2017)Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality in both developed and developing countries; and account for around 30% of all deaths worldwide. Reports indicate that nanoparticle (NP) based drug ... -
Synthesis and Physicochemical Characterisation of Poly (?-caprolactone) Nanoparticles for Delivery of Propranolol
(University of the Western Cape, 2017)Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality in both developed and developing countries; and account for around 30% of all deaths worldwide. Reports indicate that nanoparticle (NP) based drug ... -
Tacrine, trolox and tryptoline as lead compounds for the design and synthesis of multi-target drugs for Alzheimer's disease therapy
(University of the Western Cape, 2016)The cascade of neurotoxic events involved in the pathogenesis of Alzheimer's disease may explain the inefficacy of currently available treatment based on acetylcholinesterase inhibitors (AChEI - donepezil, galantamine, ... -
Taste-masking of efavirenz through microencapsulation
(University of the Western Cape, 2021)It is a well-known fact that a significant gap exists in the development of child-friendly dosage forms, detrimentally affecting paediatric patient compliance, especially in the treatment of debilitating diseases such ... -
The development and preparation of a quality control dossier for registration of Artemisia Afra capsules for the treatment of chronic Asthma by the South African health products regulatory authority
(University of the Western Cape, 2018)The aim of this study was to determine quality control specifications needed for a dossier and an investigator's brochure of A. afra capsules, which can be used to motivate the registration and clinical testing of A. afra ... -
The development of a study protocol, and ethics and regulatory approval documentation, for evaluation of clinical efficacy of Sutherlandia frutescens in adult type-2 diabetics
(University of the Western Cape, 2018)The prevalence of diabetes mellitus is increasing worldwide and it is becoming a significant medical problem in low- and middle-income countries. The condition can be controlled with a lifelong commitment to blood sugar ... -
The use of complementary and alternative medicines in the treatment of menopausal symptoms by private healthcare patients in Pretoria, South Africa
(University of the Western Cape, 2017)BACKGROUND The use of complementary and alternative medicine (CAM) is widespread in the treatment of menopausal symptoms. While observational studies indicate that CAMs can bring some relief of symptoms, there is mixed ... -
Traditional, complementary and alternative medicine in Botswana: patients’ attitudes, knowledge and use
(University of the Western Cape, 2017)BACKGROUND: The purpose of this study was to determine use, knowledge and attitudes towards traditional, complementary and alternative medicine (TCAM) in Botswana among people who visit public health facilities. PRIMARY ... -
The transition of regulatory services from drug regulatory unit to Botswana medicines regulatory authority: an evaluation of the changes in regulatory services from the industry’s perspective
(University of the Western Cape, 2023)The Drug Regulatory Unit (DRU) was established by the Ministry of Health (MoH) to enforce the Drugs and Related Substances Act of 1992 in line with the Botswana National Drug Policy (BNDP) adopted in 2002 and the National ... -
Transparency in medicines registration decision making: A closer look at National Medicines Regulatory Authorities (NMRAs) within the Southern African Development Community (SADC) region.
(University of the Western Cape, 2020)Medicines registration decision-making and regulatory best practice involve transparent and consistent rule making and processes with publicly available published assessment decisions and reports (Kaine, 2020). Publication ... -
Treatment outcomes in patients infected with multidrug resistant tuberculosis and in patients with multidrug resistant tuberculosis coinfected with human immunodeficiency virus at Brewelskloof Hospital
(University of the Western Cape, 2012)Many studies have reported low cure rates for multidrug-resistant tuberculosis (MDRTB) patients and MDR-TB patients co-infected with human immunodeficiency virus (HIV). However, little is known about the effect of HIV ... -
Use and consumer perceptions of dietary supplements in the fitness community of Gaborone, Botswana
(University of Western Cape, 2020)Health authorities around the world, including stringent ones, struggle to regulate dietary supplements. Health claims and actual effects of these products on users therefore are not adequately studied and monitored. In ... -
The use of dioxy MP 14 (stabilized aqueous chlorine dioxide) to control environmental airborne microorganisms
(2009)Dioxy MP 14 is a locally developed form of stabilized chlorine dioxide in an aqueous medium. It has all the sanitizing properties of chlorine dioxide gas, a neutral compound of chlorine in the +IV oxidation state, which ... -
The use of Dioxy MP 14 (stabilized aqueous chlorine dioxide) to control environmental airborne microorganisms
(University of the Western Cape, 2009)Dioxy MP 14 is a locally developed form of stabilized chlorine dioxide in an aqueous medium. It has all the sanitizing properties of chlorine dioxide gas, a neutral compound of chlorine in the +IV oxidation state, which ... -
Venous thromboembolism risk assessment and prophylaxis in selected public sector hospitals in the Cape Town metropole
(University of the Western Cape, 2021)Background: Venous thromboembolism (VTE) is reported to be the leading cause of death in hospitalised patients worldwide. Thromboprophylaxis provides a well-established and evidence-based approach to preventing VTE. This ...