School of Pharmacy
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Ongoing development of guidelines for biosimilar medicines assessment in Uganda: Critical evaluation and recommendations for inclusion
(University of Western Cape, 2020)A Biosimilar is defined as a biologic product that is similar but not identical to the reference/originator biologic product. Biologic products have raised hopes of improving the quality of life especially in the treatment ... -
Review of medicine registration system in Tanzania
(University of the Western Cape, 2019)Registration of medicines is an essential function of the national medicine regulatory system of any country. Since the start of the medicine registration system in Tanzania in early 2000s, no systematic review has been ... -
Review of medicine registration system in Tanzania
(University of the Western Cape, 2019)Registration of medicines is an essential function of the national medicine regulatory system of any country. Since the start of the medicine registration system in Tanzania in early 2000s, no systematic review has been ... -
Discovery of anti-mycobacterial natural products from South African marine algae
(University of the Western Cape, 2019)Tuberculosis is a communicable disease which affects millions of people around the world. Although the case reports are declining, the eradication rate of this disease is far too slow. Natural products have played a key ... -
Service learning in pharmacy: Evaluation of tuberculosis screening by pharmacy students in primary health care facilities.
(University of the Western Cape, 2019)Background: Tuberculosis (TB) is one of the arms of the so-called quadruple burden of disease in South Africa. One of the major impediments to TB control is failure to detect the disease, and undiagnosed cases in the ... -
Population pharmacokinetics of terizidone and cycloserine in patients with drugresistant tuberculosis
(University of the Western Cape, 2019)Introduction: Drug-resistant tuberculosis remains a major world health problem and one of the leading cause of death worldwide. Despite adequate adherence to antituberculosis drugs by patients, the emergence of drug-resistance ... -
Evaluation and comparison of current legal and regulatory framework for traditional medicines in five selected African countries: A move towards harmonization of regulation of traditional medicines in Africa.
(University of the Western Cape, 2019)Background: In Africa, traditional medicine (TM) practice has been in existence since time immemorial as the major source of pharmacotherapy. However, unlike orthodox medicines TM policies and regulations are not formalised ... -
Knowledge-based integration of Zimbabwean traditional medicines into the National Healthcare System: A case study of prostate cancer
(University of the Western Cape, 2017)This study sought to identify the bottlenecks in the promotion of Zimbabwean Traditional Medicines (ZTMs) towards improving the national healthcare delivery system. The indigenous medicines lost value and recognition to ... -
Knowledge, perceptions and practices of risk-based monitoring among clinical practitioners in the United States
(University of the Western Cape, 2018)This study investigated the current knowledge, perceptions, and practices of Risk-Based Monitoring (RBM) using written and verbal responses to an ethics review board approved questionnaire. Responses were collected from ... -
Bioassay guided fractionation of Angiotensin converting enzyme inhibitor compound from Hypericum perforatum
(University of the Western Cape, 2019)Due to the contribution of hypertension to various cardiovascular diseases, many studies are currently focused on identifying efficient bioactive compounds with antihypertensive activity and thus reducing the levels of ... -
The availability of persons nominated for adverse drug reporting and associated challenges in Gauteng regional and district public hospitals
(University of the Western Cape, 2019)Background and Objectives: The reporting of adverse drug reactions (ADRs) is a major public health necessity. It is estimated that only six to 10 percent of all ADRs are reported worldwide. This number is far less than the ... -
Design and evaluation of fast dispersible tablets of lamivudine using selected natural superdisintegrants
(University of the Western Cape, 2018)Fast dispersible tablets (FDTs) are solid single-unit dosage forms that are placed in the mouth and allowed to disperse or dissolve in the saliva without the need of water. The basic approach to formulating FDTs consists ... -
Formulation and evaluation of polymeric micelles for improved oral delivery of tenofovir disoproxil fumarate and zidovudine using poly-lactic-co-glycolic acid nanoparticles
(University of the Western Cape, 2018)Background: Tenofovir disoproxil fumarate (TDF) and Zidovudine (AZT) are both nucleotide and nucleoside analogue reverse transcriptase inhibitors (NtRTIs and NRTIs), respectively. They are used for the management and ... -
Polycyclic propargylamine derivatives as multifunctional neuroprotective agents
(University of the Western Cape, 2018)The abnormal death of neurons in the central nervous system of individuals suffering from neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis, ... -
Community pharmacists’ knowledge, attitude and practices on adverse drug reaction reporting in South Africa
(University of the Western Cape, 2018)Pharmacovigilance involves the management of sub-standard drugs, medication errors, ―off-licence‖ drugs, abuse and misuse, lack of efficacy, poisoning, adverse drug reactions (ADRs), drug interactions, expired stock ... -
Evaluation of reporting all types of adverse drug reactions by parents of children younger than 18 years in South Africa
(University of the Western Cape, 2019)Introduction: Medicines are created with the intention of helping patients but may be harmful to the patient by causing adverse reactions. The effect of adverse drug reactions (ADRs) on patients has become more evident ... -
Active encapsulation of diclofenac sodium into liposomes for ophthalmic preparations
(University of the Western Cape, 2018)Liposomes as a drug carrier in the pharmaceutical industry has gained currency since its discovery in 1965 by Bangham A. D. Liposomes have been shown to improve bioavailability as they can be delivered to target sites ... -
Antimicrobial discovery from South African marine algae
(University of the Western Cape., 2018)Antimicrobials are chemical compounds that destroy or inhibit the growth of microorganisms. The majority of these antimicrobials are actually natural products or natural product derived with key examples being the pioneer ... -
A Reductionistic Epistemology utilizing Brain Laterality which Investigates Pharmacists' Ideal Interactive Environment
(University of the Western Cape, 2018)The brain laterality of pharmacists may influence where the pharmacists are best suited to work. Brain laterality refers to the asymmetry of the hemispheres of the brain with regard to specific cognitive functions, such ... -
An investigation into the competency framework required for the responsible pharmacist in the pharmaceutical manufacturing sector in South Africa
(The University of the Western Cape, 2017)The pharmaceutical manufacturing sector operates within a highly regulated environment, with companies accountable to South African statutory bodies. The responsible pharmacist (RP) is responsible for their company’s ...
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