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Current practices of urinary tract infection management: An observational study at primary healthcare level
(University of Western Cape, 2021)Antibiotic resistance (ABR) is a global healthcare burden complicating the treatment of various infections. The infectious diseases burden is heavy in primary care. Urinary tract infections (UTIs) are common outpatient ... -
Structure-Based Virtual Screening of Selected Malaria Box Compounds Against a Multi-Staged Protein (Falstatin) in Plasmodium falciparum
(University of the Western Cape, 2021)Malaria disease poses substantial health risks to many nations, especially in Africa, where it primarily affects pregnant women, children, and immunocompromised patients. However, current antimalarial drugs have limitations ... -
Situation analysis study on nanomedicines regulation and assessment practices in Zazibona active countries
(University of Western Cape, 2021)Nanomedicines are loosely defined as medicines that seek to apply nanotechnology. Currently, nanomedicines are available for clinical use, including treatments for cancer, high cholesterol, hepatitis, COVID-19 vaccination, ... -
Pharmacological characterization and chemo-informatics analysis of compounds from leonotis leonurus
(University of Western Cape, 2021)The central nervous system (CNS), consisting of the brain and the spinal cord, is responsible for integrating sensory information and influencing most bodily functions . The CNS is protected from toxic and pathogenic ... -
An investigation into the medicinal properties of Tulbaghia alliacea phytotherapy
(University of the Western Cape, 2009)The reproductive health of individuals is severely compromised by HIV infection, with candidiasis being the most prevalent oral complication in patients. Although not usually associated with severe morbidity, oropharyngeal ... -
Taste-masking of efavirenz through microencapsulation
(University of the Western Cape, 2021)It is a well-known fact that a significant gap exists in the development of child-friendly dosage forms, detrimentally affecting paediatric patient compliance, especially in the treatment of debilitating diseases such ... -
Pharmacological Characterization and Chemo-informatics analysis of Compounds from Leonotis leonurus.
(2021)The central nervous system (CNS), consisting of the brain and the spinal cord, is responsible for integrating sensory information and influencing most bodily functions . The CNS is protected from toxic and pathogenic ... -
The physicochemical characterisation, compatibility testing and solid-state form screening of terizidone - Pyridoxine combinations
(University of Western Cape, 2021)Terizidone (TZD) is considered an essential anti-tuberculosis drug and in South Africa it is prescribed as part of the multi-drug resistant tuberculosis (MDR-TB) treatment regimen. From a literature study it became ... -
Effects of Leonotis leonurus aqueous extract on the isolated perfused rat heart
(University of the Western Cape, 2007)An aqueous extract prepared from the leaves and smaller stems of Leonotis leonurus was used to investigate the potential effects on certain cardiovascular parameters, such as left ventricular systolic pressure, end-diastolic ... -
An investigation into combined amorphous form of sufadoxine, pyrimethamine and azithromycin
(University of Western Cape, 2021)Malaria remains one of the top mortality causes in the sub-Saharan African region, especially among pregnant women and infants. Despite several measures being implemented within the affected areas such as the use of ... -
An assessment of current practice patterns of TB/HIV at primary healthcare clinics in the Western Cape and a needs assessment for clinic-based training among final year pharmacy students
(University of the Western Cape, 2010)Tuberculosis (TB) is a major contributor to the disease burden in developing countries resulting in deaths of approximately 2 million people a year. South Africa (SA) has one of the highest annual TB incidences with an ... -
Venous thromboembolism risk assessment and prophylaxis in selected public sector hospitals in the Cape Town metropole
(University of the Western Cape, 2021)Background: Venous thromboembolism (VTE) is reported to be the leading cause of death in hospitalised patients worldwide. Thromboprophylaxis provides a well-established and evidence-based approach to preventing VTE. This ... -
Investigating the Perception of the Influence of Pharmaceutical Marketing on Pharmacists and Doctors Dispensing and Prescribing Practices.
(University of the Western Cape, 2021)Pharmaceutical marketing via a wide range of promotional tools to doctors and pharmacists is one of the primary methods used by the pharmaceutical industry to drive product sales. Pharmaceutical representatives are the ... -
Risk based approach of post- approval changes in central America and Dominican republic, identifying opportunities for convergence with EMA and FDA
(University of Western Cape, 2021)In Central American countries (Guatemala, El Salvador, Honduras, Nicaragua, Costa Rica and Panama) and Dominican Republic (DR) the approval timelines for major changes are described ranging from 12 to 18 months, these ... -
Exploration of the training/educational background and the roles of regulatory affairs associates/officers in selected South African based pharmaceutical companies in Gauteng province
(University of Western Cape, 2021)Regulatory Affairs (RA), within the pharmaceutical business, could be a profession that covers different registration parameters of a pharmaceutical product. This is a profession that was developed to protect the public ... -
Investigation of the mechanism of fenfluramine-induced pulmonary phospholipidosis in the rat lung model
(University of the Western Cape, 1993)The aim of this study was to investigate the mechanism of fenfluramine-induced pulmonary phospholipidosis, by comparing the profile and levels of induced phospholipids in the rat and the mode of phospholipase inactivation, ... -
Pharmacist educational outreach for improved primary care of asthma in children
(University of the Western Cape, 2001)Underdiagnosis and undertreatment of asthma in children are barriers to optimal health care delivery and health, incurring substantial costs to both the families and health services. A tailored multifaceted educational ... -
An assessment of current practice patterns of TB/HIV at primary health care clinics in the Western Cape and a needs assessment for clinic-based training among final year pharmacy students
(University of the Western Cape, 2010)Tuberculosis and mv Tuberculosis (TB) is a major contributor to the disease burden in developing countries resulting in the deaths of approximately 2 million people a year. South Africa (SA) has one ( of the highest ... -
The formulation and evaluation of indomethacin tablets
(University of the Western Cape, 1998)The overall objective of this research is to attempt to produce, by direct compression, indomethacin tablets which have good dissolution characteristics and an improved bioavailability profile, when compared to the capsule ... -
An investigation of the production of non-coated sustained release beads by extrusion and Spheronization
(University of the Western Cape, 1995)The popularity and increasing complexity of sustained release dosage forms has resulted in increased costs to the patient. One approach to achieve cheaper, yet effective, sustained release medication is through the ...
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