Magister Scientiae - MSc (Pharmaceutical Chemistry)
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Recent Submissions
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Discovery of heat shock protein90 inhibitors using structured-based virtual screening
(University of the Western Cape, 2023)Alzheimer's disease (AD) is the most common irreversible dementia, caused by accumulation of protein aggregates in the central nervous system, with symptoms that include memory loss and behavioural abnormalities. Cholinesterase ... -
The implementation of the African union model law on medical products regulation and the establishment of the African medicines agency
(University of the Western Cape, 2022)Within Africa, there is insufficient access to quality, safe, efficacious and affordable medical products which can partly be attributed to lack of robust regulatory systems, a lack of competent regulatory professionals ... -
Assessing the influence of electronic media on student perceptions towards antibiotic resistance
(University of the Western Cape, 2022)Antimicrobial resistance (AMR) and the reduced number of new antibiotic discoveries impose a major threat to the quality of human life and effective treatment options. Antibiotic resistant infections require prolonged ... -
A comparison between estimated renal function from point-of care derived cystatin c measurements and serum creatinine derived measurements
(University of the Western Cape, 2022)Serum Creatinine (SCr) is the most commonly used and cost effective biomarker used to quantify estimated glomerular filtration rate. However, creatinine is affected by anthropometric parameters such as muscle mass, age ... -
Synthesis and characterisation of biomimetic immunostimulatory lipid-polymer hybrid nanoparticles
(University of the Western Cape, 2022)Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis), remains a fatal infectious disease and one of the top ten leading causes of mortality, particularly in developing countries. Current drug therapy ... -
Homology modelling and characterization of three-dimensional (3d) protein structures of selected variants of cyp3a4
(University of the Western Cape, 2022)The efficacy and toxicity of several drugs and prodrugs are influenced by the interindividual genetic variations in drug-metabolising enzymes. Cytochrome P450 enzymes constitute the major metabolising enzymes in humans. ... -
Investigating the Perception of the Influence of Pharmaceutical Marketing on Pharmacists and Doctors Dispensing and Prescribing Practices.
(University of the Western Cape, 2021)Pharmaceutical marketing via a wide range of promotional tools to doctors and pharmacists is one of the primary methods used by the pharmaceutical industry to drive product sales. Pharmaceutical representatives are the ... -
Biosimilar’s Growth in Pharmerging Markets: An Analysis of the Regulatory Environments
(University of the Western Cape, 2020)The introduction of biosimilars to health care markets across the globe has had some success in increasing competition and improving the cost of healthcare. While savings are important for driving the biosimilar uptake, ... -
Chalcone and curcumin hybrids of indole propargylamines as multifunctional neuroprotective agents
(University of the Western Cape, 2020)Neurodegenerative disorders (NDs) are a range of chronic brain disorders that includes amongst others motor function loss. Parkinson’s disease (PD) is one of the common NDs that has an insidious onset and diagnosed when ... -
Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
(University of the Western Cape, 2020)Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are ... -
Synthesis and evaluation of 7-substituted 3-propargylamine coumarin derivatives as multifunctional monoamine oxidase and cholinesterase inhibitors for Alzheimer’s Disease treatme
(University of Western Cape, 2020)Alzheimer’s Disease (AD) is a neurodegenerative disease which results from the irreversible loss of neurons in the brain. The disease is characterized by progressive cognitive impairment with recurrent short-term memory ... -
Discovery of anti-mycobacterial natural products from South African marine algae
(University of the Western Cape, 2019)Tuberculosis is a communicable disease which affects millions of people around the world. Although the case reports are declining, the eradication rate of this disease is far too slow. Natural products have played a key ... -
Active encapsulation of diclofenac sodium into liposomes for ophthalmic preparations
(University of the Western Cape, 2018)Liposomes as a drug carrier in the pharmaceutical industry has gained currency since its discovery in 1965 by Bangham A. D. Liposomes have been shown to improve bioavailability as they can be delivered to target sites ... -
Post-market assessment of the quality of first line regimen fixed-dose combination antiretrovirals in South Africa
(University of the Western Cape, 2017)The rapid increase in access to new antiretrovirals (ARVs) worldwide and, especially in sub-Saharan Africa, coupled with the well-documented problem of poor quality ARVs in developing countries has underscored the need for ... -
Evaluation of the effect of polyethylene glycol incorporation on the performance of poly(lactic-co-glycolic acid) nanoparticles
(University of the Western Cape, 2016)Nanoparticle drug delivery is challenged by the binding of proteins in blood which result in their rapid removal from the circulatory system. Nanoparticles engineered to delay protein binding have shown to have extended ... -
Novel adamantane-chloroquinolin conjugates to overcome plasmodium falciparum chloroquine resistance
(University of the Western Cape, 2017)Malaria poses devastating health and socioeconomic outcomes on global health especially among pregnant women and children below the age of 5 in endemic areas. This is exacerbated by Plasmodium falciparum resistance to ...
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