Browsing School of Pharmacy by Title
Now showing items 117-136 of 224
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Homology modelling and characterization of three-dimensional (3d) protein structures of selected variants of cyp3a4
(University of the Western Cape, 2022)The efficacy and toxicity of several drugs and prodrugs are influenced by the interindividual genetic variations in drug-metabolising enzymes. Cytochrome P450 enzymes constitute the major metabolising enzymes in humans. ... -
Hybrid molecules as inhibitors of the monoamine oxidases and caspase 3 for neurodegenerative disorders
(University of the Western Cape, 2016)Neurodegenerative diseases are multifactorial in nature, and taking the complex nature of these disorders into consideration, multi-target directed ligands may present as better options to treat these disorders than the ... -
Identification of potential antibiofilm hit compounds from two African natural product database against multi-drug resistant staphylococcus aureus: an in silico study
(University of the Western Cape, 2023)One of the crucial ways by which Staphylococcus aureus develops resistance to antibiotics is biofilm formation, a protective mechanism involving extracellular polymeric substance (EPS) matrix that shields microorganisms ... -
The impact an accredited third party assessor will have on the regulator’s response time
(University of the Western Cape, 2014)Globally regulators have been under scrutiny for delays in market application (MA) approvals. The main issue that surfaces in studies related to these delays is a shortage in competent reviewers. The concept of a third ... -
The impact of Niacin on PCSK9 levels in vervet monkeys (Chlorocebus aethiops)
(University of the Western Cape, 2020)Cardiovascular diseases (CVDs) such as ischaemic heart diseases, heart failure and stroke remain a major cause of death globally. Various deep-rooted factors influence CVD development; these include but are not limited ... -
The impact of Niacin on PCSK9 levels in vervet monkeys (Chlorocebus aethiops)
(University of Western Cape, 2020)Cardiovascular diseases (CVDs) such as ischaemic heart diseases, heart failure and stroke remain a major cause of death globally. Various deep-rooted factors influence CVD development; these include but are not limited ... -
The impact of Niacin on PCSK9 levels in vervet monkeys (Chlorocebus aethiops)
(University of the Western Cape, 2020)Cardiovascular diseases (CVDs) such as ischaemic heart diseases, heart failure and stroke remain a major cause of death globally. Various deep-rooted factors influence CVD development; these include but are not limited to ... -
The impact of universal health coverage and national health expenditure on the main health determinants on central America countries and the Caribbean
(University of Western Cape, 2020)Health is considered as a sensitive marker of the sustainable development of a population. In Central America and Caribbean (CAC) region, the majority of countries are considered middle-income economies with significant ... -
The implementation of the African union model law on medical products regulation and the establishment of the African medicines agency
(University of the Western Cape, 2022)Within Africa, there is insufficient access to quality, safe, efficacious and affordable medical products which can partly be attributed to lack of robust regulatory systems, a lack of competent regulatory professionals ... -
The influence of the proposed professional fee for community pharmacists on prescription income
(University of the Western Cape, 2002)prescription pricing in community pharmacies in South Africa involves a percentage mark-up on the cost of the product, followed by a varying discount to either the client or the medical scheme. The Pharmaceutical Society ... -
Innovator Medicines Versus Generic Medicine Package Inserts Safety Amendments, the Reality in South Africa
(University of the Western Cape, 2017)Availability of clinically relevant and unbiased medicine information goes a long way in promoting rational use of medicines. The package insert (PI) is one of the sources of information utilised by healthcare professionals ... -
Integrating Complementary and Alternative Medicines into Pharmacy Practice: Identifying challenges in meeting professional responsibilities and training needs
(University of the Western Cape, 2017)Community pharmacies are popular suppliers of complementary and alternative medicines (CAMs) and pharmacists encounter requests from consumers for information on them. The purpose of this study was to assess the extent to ... -
Inter-professional collaboration between general practitioners and community pharmacists: general practitioners’ perspectives
(University of Western Cape, 2012)The global movement towards enhancing inter-professional collaboration in patient care is in light of the increasing potency of drugs and complexity of drug regimens, particularly in the chronically ill where poly-pharmacy ... -
Investigating the Economic Impact of Mandatory Electronic Prescribing Requirements in the United States
(University of the Western Cape, 2017)Technological advancements applied to healthcare may holistically improve the economic burden of prescription medication costs. United States legislative actions requiring utilization of electronic prescribing (e-prescribing) ... -
Investigating the Perception of the Influence of Pharmaceutical Marketing on Pharmacists and Doctors Dispensing and Prescribing Practices.
(University of the Western Cape, 2021)Pharmaceutical marketing via a wide range of promotional tools to doctors and pharmacists is one of the primary methods used by the pharmaceutical industry to drive product sales. Pharmaceutical representatives are the ... -
An investigation into combined amorphous form of sufadoxine, pyrimethamine and azithromycin
(University of Western Cape, 2021)Malaria remains one of the top mortality causes in the sub-Saharan African region, especially among pregnant women and infants. Despite several measures being implemented within the affected areas such as the use of ... -
An investigation into the competency framework required for the responsible pharmacist in the pharmaceutical manufacturing sector in South Africa
(The University of the Western Cape, 2017)The pharmaceutical manufacturing sector operates within a highly regulated environment, with companies accountable to South African statutory bodies. The responsible pharmacist (RP) is responsible for their company’s ... -
An investigation into the impact of training pharmacists' assistants in early recognition and referral procedures on tuberculosis referral rates in the Cape Town metropole
(University of the Western Cape, 2009)Due to the resurgence of TB globally, in 2006 the WHO and the STOP-TB partnership launched a Global plan to STOP TB. This is a l0 year plan which aims to save l4 million lives between 2006 and 2015. Specific targets were ... -
An investigation into the medicinal properties of Tulbaghia alliacea phytotherapy
(University of the Western Cape, 2009)The reproductive health of individuals is severely compromised by HIV infection, with candidiasis being the most prevalent oral complication in patients. Although not usually associated with severe morbidity, oropharyngeal ... -
An investigation into the medicinal properties of Tulbaghia alliacea phytotherapy
(University of the Western Cape, 2009)The reproductive health of individuals is severely compromised by HIV infection, with candidiasis being the most prevalent oral complication in patients. Although not usually associated with severe morbidity, oropharyngeal ...